右美托咪定复合尼卡地平对老年骨科手术患者控制性降压的影响

发布时间：2018-03-05 20:18

本文选题：右美托咪定　切入点：尼卡地平　出处：《中国老年学杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的探讨右美托咪定复合尼卡地平对老年患者在骨科手术全身麻醉中控制性降压的作用。方法 168例需行骨科手术的老年患者,根据降压用药不同分为两组各84例,对照组单纯使用尼卡地平控制性降压,观察组联合应用尼卡地平和右美托咪定控制性降压。比较两组患者手术过程中术野清晰度,血流动力学变化以及对肾素-血管紧张素-醛固酮系统(RAAS)系统的影响。结果观察组手术视野清晰度评分为(2.05±0.21)级,显著低于对照组(2.53±0.26)级(P0.05),级别越低清晰程度越高,观察组术视野清晰度明显优于对照组;观察组术中出血量以及术中补液量均显著少于对照组,排尿量显著多于对照组(均P0.05);观察组血流动力学较对照组稳定,并且对照组各时间段肾素(PRA)、血管紧张素Ⅱ(AT-Ⅱ)、醛固酮(ALD)含量均显著多于观察组(P0.05)。结论联合应用尼卡地平和右美托咪定可有效维持血流动力稳定性,并且能够提高手术视野清晰度,减少手术时间,控制性降压效果理想。
[Abstract]:Objective to investigate the effects of dexmedetomidine combined with nicardipine for controlled hypotension in elderly patients in Department of orthopedics surgery during general anesthesia. Methods 168 patients underwent Department of orthopedics surgery in elderly patients, according to the blood pressure medication were divided into two groups with 84 cases in each group, the control group were treated with nicardipine controlled pressure reduction, the observation group combined with nicardipine and dexmedetomidine for controlled hypotension. Comparison of two groups of patients during the operation of the wild clarity, the hemodynamic changes of the renin angiotensin aldosterone system (RAAS) system. Results in the observation group, the definition of surgical field score (2.05 + 0.21), significantly lower than the control group (2.53 + 0.26) grade (P0.05), the lower the level of clarity is high, the vision clarity in observation group was significantly better than the control group; the observation group of intraoperative bleeding fluid volume and volume were significantly less than the control group, urine volume significantly more than the control group ( P0.05); the observation group compared with the control group, hemodynamic stability, and the control group each time (PRA), renin angiotensin II (AT- II), aldosterone (ALD) were significantly more than the observation group (P0.05). Conclusion the combination of nicardipine and dexmedetomidine can effectively maintain hemodynamic stability. And can improve the definition of surgical field, reduce the operation time, control the ideal antihypertensive effect.

【作者单位】：海南省农垦那大医院麻醉科;
【分类号】：R614

【共引文献】