不同剂量普瑞巴林对骨科术后早期疼痛的影响

发布时间：2018-03-06 15:23

本文选题：超前镇痛　切入点：普瑞巴林　出处：《中国临床药理学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的观察骨科腰椎手术患者用不同剂量的普瑞巴林预先给药联合自控镇痛(PCA)对术后早期疼痛的影响。方法择期进行腰椎管狭窄症腰椎椎板减压手术的患者54例,随机分为高、中、低剂量组,每组18例。分别于麻醉前2 h口服普瑞巴林300,150,75 mg,术后脱机即开始自控镇痛,记录术后2,6,12,24 h患者的视觉模拟评分(VAS)及术后24 h内自控镇痛药物用量及药物不良反应发生率。结果术后2 h,高、中、低剂量组VAS评分分别为3.72±1.27,3.67±1.14,4.78±1.31,高、中剂量组与低剂量组比较,差异有统计学意义(P0.05)。术后6 h,高、中、低剂量组VAS评分分别为3.06±0.80,3.28±1.49,4.00±0.69,高剂量组与低剂量组比较,差异有统计学意义(P0.05)。术后12 h,高、中、低剂量组VAS评分分别为2.28±0.67,3.11±1.28,3.33±0.84,高、中剂量组与低剂量组比较,差异有统计学意义(P0.05)。术后24 h,高、中、低剂量组VAS评分分别为2.17±0.62,2.83±1.10,2.83±0.71,差异无统计学意义(P0.05)。高剂量组出现头晕伴恶心呕吐1例,嗜睡1例,恶心呕吐1例,药物不良反应发生率为16.67%(3/18例);中、低剂量组分别出现恶心呕吐1例,药物不良反应均为5.56%(1/18例),3组药物不良反应发生率差异无统计学意义(P0.05)。结论普瑞巴林预先给药用于骨科手术,术后早期镇痛效果良好,并且药物不良反应发生率低,300 mg的预先给药可能是一个较好的方案。
[Abstract]:Objective To observe the patients of Department of orthopedics lumbar surgery with different dose of pregabalin administered with patient-controlled analgesia in advance (PCA) effect on early postoperative pain. Methods 54 patients undergoing lumbar spinal stenosis lumbar decompression surgery, were randomly divided into high, low dose group, each group of 18 cases respectively before anesthesia, 2. H 300150,75 mg oral pregabalin, postoperative analgesia is offline, 2,6,12,24 h of postoperative patients with visual analogue scale (VAS) and postoperative adverse reactions within 24 h analgesic drugs and incidence. Results after 2 h, high, low dose group, VAS score was 3.72 + 1.27,3.67 + 1.14,4.78 + 1.31, high, middle dose group and low dose group, the difference was statistically significant (P0.05). After 6 h, high, low dose group, VAS score was 3.06 + 0.80,3.28 + 1.49,4.00 + 0.69, high dose group and low dose group, the difference was statistically Statistically significant (P0.05). After 12 h, high, low dose group, VAS score was 2.28 + 0.67,3.11 + 1.28,3.33 + 0.84, high, middle dose group and low dose group, the difference was statistically significant (P0.05). After 24 h, high, low dose group, VAS score were 2.17 + 0.62,2.83 + 1.10,2.83 + 0.71, the difference was not statistically significant (P0.05). Dizziness nausea and vomiting in 1 cases with high dose group, 1 cases in 1 cases of drowsiness, nausea and vomiting, the incidence of adverse reaction was 16.67% (3/18 cases), low dose group; there were 1 cases of nausea and vomiting, no drugs adverse reactions were 5.56% (1/18 cases), drug adverse reactions of the 3 groups there was no significant difference between them (P0.05). Conclusion pregabalin pretreatment for Department of orthopedics operation, postoperative analgesia effect is good, and the incidence of adverse drug reactions, 300 mg pretreatment may be a better solution.

【作者单位】：吉化集团公司总医院骨科;吉化集团公司总医院麻醉科;
【分类号】：R614

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