右美托咪定与咪达唑仑复合腰硬联合麻醉对经尿道前列腺电切术患者术中应激反应和术后认知功能的影响

发布时间：2018-03-08 22:38

  本文选题：经尿道前列腺电切术　切入点：右美托咪定　出处：《中国现代医学杂志》2015年19期 　论文类型：期刊论文

【摘要】：目的分析右美托咪定与咪达唑仑复合腰硬联合麻醉对经尿道前列腺电切术(TURP)患者术中应激反应和术后认知功能的影响。方法选择在该院接受住院治疗的TURP患者作为研究对象,随机分为咪达唑仑复合腰硬联合麻醉的对照组、右美托咪定复合腰硬联合麻醉的观察组,比较两组患者的血清S100β水平、应激水平及术后认知功能等差异。结果观察组患者接受右美托咪定复合腰硬联合麻醉后各个时间点的血清S100β水平均明显低于对照组(P0.05)。观察组患者的应激指标肾上腺素(E)、去甲肾上腺素(NE)、肾素(R)以及血管紧张素Ⅱ(ATⅡ)水平均明显低于对照组(P0.05)。观察组患者术后各个时间点的认知功能评分均明显高于对照组(P0.05)。结论右美托咪定复合腰硬联合麻醉可以更为有效的减轻围术期应激反应,减少对患者认知功能的抑制作用。
[Abstract]:Objective to analyze the effect of combined epidural anesthesia of dexmetomidine and midazolam on stress response and postoperative cognitive function in patients undergoing transurethral resection of the prostate (TURP). They were randomly divided into two groups: the control group with midazolam combined with spinal-epidural anesthesia and the observation group with dexmetomidine combined with spinal-epidural anesthesia. The serum S100 尾 levels were compared between the two groups. Results the levels of serum S100 尾 in the observation group were significantly lower than those in the control group at all time points after dexmetomidine combined with spinal epidural anesthesia. The stress index of the observation group was superior to that of the control group (P 0.05). The levels of adenine, norepinephrine, renin and angiotensin 鈪，

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