大鼠子宫角瘘管模型的建立

发布时间：2018-03-12 23:24

本文选题：大鼠　切入点：子宫角　出处：《中国比较医学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨在大鼠子宫角安置瘘管导管的可行性。方法对大鼠进行麻醉后,在近子宫体端子宫角放置瘘管导管,并进行组织病理学和妊娠功能的研究。结果大鼠子宫内膜厚度瘘管模型组内瘘管留置侧子宫角(497.68±81.64)μm与对照组(537.90±77.29)μm和瘘管模型组内对侧子宫角(503.56±76.34)μm相比差异不显著(P0.05);大鼠胚胎植入数量瘘管模型组(9.67±1.95)个与对照组(12.15±2.06)个相比显著减少(P0.05);瘘管模型组内瘘管侧子宫角(5.83±3.54)个与对侧子宫角(6.17±3.67)个相比差异不显著(P0.05)。结论子宫角瘘管导管模型对大鼠子宫组织结构影响较小,能够满足向子宫腔内长期注射病原微生物或者化学药物等的试验要求。
[Abstract]:Objective to investigate the feasibility of fistula catheter placement in the uterine horn of rats. Methods after anaesthesia, fistula catheter was placed in the proximal uterine horn of the rat. The histopathology and pregnancy function were also studied. Results there was no significant difference in endometrial thickness fistula model group (497.68 卤81.64) 渭 m compared with the control group (537.90 卤77.29) 渭 m and the contralateral uterine horn (503.56 卤76.34) 渭 m in the fistula model group. The number of Fistula in the Fistula Model Group (9.67 卤1.95) was significantly lower than that in the control group (12.15 卤2.06), while there was no significant difference between the Fistula Model Group and the contralateral uterine horn group (5.83 卤3.54) and the contralateral uterine horn (6.17 卤3.67). The influence of uterine tissue structure is small, It can meet the requirements of long-term injection of pathogenic microorganisms or chemical drugs into uterine cavity.
【作者单位】：东北大学生命科学与健康学院;
【基金】：基金项目教育部中央高校基本科研业务费(N130420001)
【分类号】：R-332

【参考文献】