不同剂量右美托咪定对麻醉苏醒期躁动的治疗效果及安全性

发布时间：2018-03-18 21:07

本文选题：临床观察　切入点：下肢手术　出处：《北方药学》2016年06期 　论文类型：期刊论文

【摘要】：目的:探析下肢手术进行不同剂量右美托咪定麻醉对苏醒期躁动的临床效果观察及安全性研究。方法:临床选择2014年6月~2015年6月本院收治的下肢手术病例100例,根据随机数字表法分为对照组和观察组,每组50例,观察组予以0.5μg/kg右美托咪定联合腰硬联合麻醉,对照组予以0.25μg/kg右美托咪定联合腰硬麻醉,记录给药前(T0)、给药5min(T1)、给药30min(T2)、给药1h(T3)、结束手术时(T4)的呼吸频率(RR)、平均动脉压(MAP)、心率(HR)等指标;比较记录给药前(T0)、给药5min(T1)、给药30min(T2)、给药1h(T3)、结束手术时(T4)的术中镇静效果。结果:观察组给药5min(T1)、给药30min(T2)、给药1h(T3)、结束手术时(T4)的RR、MAP、HR等指标显著优于对照组,差异有统计学意义(P0.05);观察组给药5min(T1)、给药30min(T2)、给药1h(T3)、结束手术时(T4)的镇静效果显著优于对照组,差异有统计学意义(P0.05)。结论:下肢手术予以0.5μg/kg右美托咪定腰硬联合麻醉术中患者生命体征平稳,镇静效果较佳,值得临床推广。
[Abstract]:Objective: to investigate the clinical effect and safety of dexmetomidine anesthesia in lower extremity operation in patients with restlessness during recovery period. Methods: from June 2014 to June 2015, 100 cases of lower extremity operation were selected. According to the random number table method, the control group and the observation group were divided into two groups, 50 cases in each group. The observation group was given 0.5 渭 g / kg dexmetidine combined with spinal-epidural anesthesia, and the control group was given 0.25 渭 g / kg dexmetidine combined with spinal-epidural anesthesia. The respiratory frequency, mean arterial pressure (MAPP), heart rate (HRR) of T0, T1, T2, T2, T3, T4 at the end of operation were recorded. Results: the intraoperative sedative effects of T0, T0, T1, T2, T3, T4 at the end of operation in the observation group were significantly better than those in the control group (5 min, 30 min, 30 min, 1 h, and 1 h, respectively), and the results showed that the RRMP-MAPHR of the observation group was significantly better than that of the control group (P < 0.05), and that of the observation group was significantly higher than that of the control group (P < 0.01). The results showed that the RRRMAPHR in the observation group was significantly better than that in the control group in 5 min, 30 min, 1 h, and 1 h, respectively. The sedation effect of the observation group was significantly better than that of the control group, and the sedation effect of the observation group was significantly better than that of the control group, and the sedative effect of the observation group was better than that of the control group, and the sedative effect of the observation group was better than that of the control group, and that of the observation group was better than that of the control group. The difference was statistically significant (P 0.05). Conclusion: the vital signs of patients undergoing lower extremity surgery with 0.5 渭 g / kg dexmetomidine were stable, and the sedation effect was better, which is worthy of clinical promotion.
【作者单位】：甘肃省武威市凉州区医院麻醉手术科;甘肃省武威市凉州区医院重症医学科;
【分类号】：R614

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