丙泊酚联合地佐辛对老年无痛肠镜应激指标的影响

发布时间：2018-03-25 00:14

  本文选题：丙泊酚　切入点：地佐辛　出处：《医学综述》2016年21期

【摘要】：目的研究丙泊酚联合地佐辛对老年无痛肠镜应激指标的影响。方法选取2014年3月至2015年4月收入无锡市锡山人民医院行无痛肠镜的老年患者220例为研究对象。按随机数字表法分为观察组和对照组,各110例。观察组使用地佐辛和丙泊酚联合麻醉(先静脉缓慢注射5 mg地佐辛,10 min后,静脉注射2.0 mg/kg丙泊酚),对照组仅使用丙泊酚麻醉(静脉注射2.0 mg/kg丙泊酚),并对两组收缩压、舒张压、心率及脉搏血氧饱和度(SpO_2),丙泊酚用量、苏醒时间及视觉模拟评分(VAS),不良反应及应激指标进行比较。结果术中,两组生命体征平稳,未出现麻药物过敏现象。术中,观察组收缩压、舒张压、心率均较对照组显著降低[(105.69±8.77)mmHg(1 mmH g=0.133 k Pa)比(122.14±9.46)mmHg、(62.34±6.76)mmHg比(78.01±9.41)mmHg、(71.30±6.44)次/min比(80.58±10.32)次/min],SpO_2较对照组显著增加[(0.986±0.011)比(0.947±0.010)],差异有统计学意义(P0.05)。观察组术中丙泊酚用量显著低于对照组[(82±8)mg比(123±19)mg],差异有统计学意义(P0.05)。术后,两组苏醒时间差异无统计学意义(P0.05)。与对照组相比,观察组术后不良反应较少,仅3例出现恶心呕吐,对照组不良反应种类及例数较多,观察组不良反应发生率低于对照组,差异有统计学意义(P0.05)。两组术中、术后皮质醇和血管紧张素Ⅱ水平均呈先升高后降低趋势,观察组变化幅度更小,两组在组间、时点间、组间·时点间交互作用差异有统计学意义(P0.05)。结论丙泊酚联合地佐辛用于对老年无痛肠镜检查和治疗中,具有治疗方便,安全性好,应激反应小的特点,值得临床推广应用。
[Abstract]:Objective to study the effect of propofol combined with dizosin on the stress index of painless enteroscopy in the elderly. Methods 220 elderly patients who received painless endoscopy from March 2014 to April 2015 in Xishan people's Hospital of Wuxi City were selected as the study objects. The method of random digital table was divided into observation group and control group. One hundred and ten patients in each group were treated with dizosin and propofol combined anesthesia (intravenous injection of 5 mg dizosin for 10 min, intravenous injection of 2.0 mg/kg propofol), and control group only with propofol anesthesia (intravenous injection of 2.0 mg/kg propofol, and systolic blood pressure in both groups). Diastolic blood pressure (DBP), heart rate (HR) and pulse oxygen saturation (SPO _ 2), propofol dosage, recovery time and visual analogue score (VASA), adverse reactions and stress indexes were compared. Results during the operation, the vital signs of the two groups were stable, and no anaphylaxis occurred during the operation. Systolic blood pressure, diastolic blood pressure, The heart rate was significantly lower than that in the control group [105.69 卤8.77)mmHg(1 mmH 0.133 KPA] than that in the control group (122.14 卤9.46 6.76)mmHg vs 78.01 卤9.41 6.76)mmHg vs 78.01 卤9.41mm / min vs 80.58 卤10.32kPa / min), and the difference was statistically significant (P 0.05). The dosage of propofol in the observation group was significantly lower than that in the control group [82 卤8)mg vs 123 卤19)mg], and the difference was significant in comparison with the control group (P < 0.05), and the dosage of propofol in the observation group was significantly lower than that in the control group [82 卤8)mg vs 123 卤19)mg]. The significance of calculation is P0.05. after operation, There was no significant difference in the recovery time between the two groups (P 0.05). Compared with the control group, the adverse reactions in the observation group were less, only 3 cases had nausea and vomiting, and the type and number of adverse reactions in the control group were more than those in the control group. The incidence of adverse reactions in the observation group was lower than that in the control group. During the operation, the levels of cortisol and angiotensin 鈪，

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