地佐辛复合麻醉对结肠癌腹腔镜手术术后患者IL-6、MDA及SOD水平影响研究

发布时间：2018-03-30 23:11

本文选题：地佐辛　切入点：复合麻醉　出处：《中国生化药物杂志》2016年04期

【摘要】：目的探讨地佐辛复合麻醉对结肠癌腹腔镜手术术后患者白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平的影响。方法收集拟行腹腔镜结肠癌根治术的患者48例,随机分为对照组和实验组,各24例,对照组给予瑞芬太尼复合麻醉,实验组给予地佐辛复合麻醉,手术后,对所有患者的血清IL-6、TNF-α、MDA及SOD水平及不良反应发生率进行检测。结果手术后,与对照组比较,实验组患者的血清IL-6、TNF-α水平较低(P0.05);实验组患者的血清MDA水平较低,SOD水平较高(P0.05);实验组患者不良反应的发生率较低(P0.05)。结论地佐辛复合麻醉能够显著降低结肠癌腹腔镜手术患者术后血清IL-6、TNF-α、MDA水平,提高血清SOD水平,有效减轻炎症及氧化应激反应,且具有较高安全性。
[Abstract]:Objective to investigate the effects of combined anesthesia with dizosin on the levels of interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪), malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with colon cancer after laparoscopic surgery.Methods 48 patients with colon cancer undergoing laparoscopic radical resection were randomly divided into control group (n = 24) and experimental group (n = 24). The control group was given remifentanil combined anesthesia, and the experimental group was given dizosin combined anesthesia.The levels of serum IL-6 TNF- 伪, SOD and the incidence of adverse reactions were measured in all patients.Results compared with the control group, the serum level of IL-6 TNF- 伪 in the experimental group was lower than that in the control group (P 0.05), the serum MDA level in the experimental group was higher than that in the control group (P 0.05), and the incidence of adverse reactions in the experimental group was lower than that in the control group (P 0.05).Conclusion combined anesthesia with dizosin can significantly reduce the level of serum IL-6 TNF- 伪, increase the level of serum SOD, reduce inflammation and oxidative stress, and have high safety in patients with colon cancer undergoing laparoscopic surgery.
【作者单位】：湖州市中心医院麻醉科;
【分类号】：R614;R735.35

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