基于微型光谱仪的麻醉深度监测技术研究

发布时间：2018-03-31 02:23

本文选题：麻醉深度　切入点：微型光谱仪　出处：《曲阜师范大学》2016年硕士论文

【摘要】：麻醉是临床手术的重要环节之一,适度的麻醉可以减轻伤病人员的痛苦。针对临床手术环境的复杂性,为了保证病人的手术安全,提高病人手术后的苏醒质量,就必须对其麻醉的深度进行合理的监测。目前,麻醉医师主要依靠个人经验和麻醉深度监测仪器判定伤病人员术中的麻醉深度。但是,因自身及外界因素的干扰,两者均会出现一定的麻醉误差。因此,对于多种监测方式相结合的复合式麻醉深度监测技术的研究就有了重要意义。为了更好的了解伤病人员在临床手术中脑血氧含量变化与其麻醉深度的关系,本文提出了一种集电子学、光谱学与麻醉学于一体的基于微型光谱仪的麻醉深度监测方法,为复合式麻醉深度的监测手段提供了一种新的方法。具体内容有:首先,介绍了人体生物组织的光学特性、光谱学理论以及脑血氧检测的理论基础。根据文献调研,论述了NIRS技术在麻醉深度监测中的可行性。其次,设计了NIRS麻醉深度监测系统,介绍了系统的整体方案流程框图、硬件设计和软件设计。利用Monte-Carlo仿真对成人脑组织模型模拟光吸收特性,确定出合理的源距离,设计出最优探头装置;根据系统设计的特点和功能要求,设计了操作简易且友好的上位机界面。最后,利用设计完成的NIRS麻醉深度监测系统进行了初步探测性实验。分别研究了前臂阻断和脑部集中精力两种状态下的组织血氧饱和度变化情况。实验结果显示:(1)前臂阻断实验表明采用NIRS技术监测组织血氧饱和度更加敏感、迅速,表征系统的有效性;(2)脑功能实验测得数据趋势图与生物医学上的理论分析趋势相一致,表明了系统的可行性。
[Abstract]:Anesthesia is one of the most important links in clinical operation. Moderate anesthesia can alleviate the suffering of the injured and sick people. In view of the complexity of the clinical operation environment, in order to ensure the patient's operation safety and improve the patient's recovery quality after operation, At present, the anesthesiologist mainly relies on personal experience and anesthetic depth monitoring instruments to determine the depth of anesthesia during the operation of the injured and sick personnel. However, due to the interference of their own and external factors, Both have a certain anesthetic error. In order to better understand the relationship between the changes of cerebral blood oxygen content and the depth of anesthesia of the injured and sick people during the clinical operation, it is of great significance to study the technology of combined depth monitoring of anesthesia, which is based on the combination of various monitoring methods. In this paper, a new method of anesthetic depth monitoring based on microspectrometer, which integrates electronics, spectroscopy and anesthesiology, is proposed, which provides a new method for the monitoring of compound anesthetic depth. The main contents are as follows: first, The optical properties of human biological tissue, the theory of spectroscopy and the theoretical basis of brain blood oxygen detection are introduced. According to the literature investigation, the feasibility of NIRS technology in depth monitoring of anesthesia is discussed. Secondly, the NIRS depth monitoring system is designed. The whole scheme flow chart, hardware design and software design of the system are introduced. The optical absorption characteristics of adult brain tissue model are simulated by Monte-Carlo simulation, the reasonable source distance is determined and the optimal probe device is designed. According to the characteristics and functional requirements of the system design, a simple and friendly upper computer interface is designed. Finally, A preliminary exploratory experiment was carried out using the NIRS anesthetic depth monitoring system designed. The changes of blood oxygen saturation in the forearm under two states of forearm occlusion and brain concentration were studied respectively. The results showed that the forearm was in the first arm. The blocking experiment showed that NIRS was more sensitive in monitoring tissue oxygen saturation. The trend map of brain function experiment is consistent with the trend of theoretical analysis in biomedicine, which indicates the feasibility of the system.
【学位授予单位】：曲阜师范大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：TH789

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