大鼠急性心肌梗死模型制备方法研究进展

发布时间：2018-03-31 03:12

本文选题：大鼠　切入点：急性心肌梗死模型　出处：《中国比较医学杂志》2017年10期

【摘要】：急性心肌梗死是危害人类生命的重大疾病之一。心肌梗死动物模型对研究人类心肌梗死的病理生理变化、诊断和治疗有着重要意义。目前心肌梗死动物模型的制备主要存在动物存活率低、繁琐复杂等问题。近年来,针对心肌梗死动物模型制备方法研究取得一些进展,在模型动物存活率、模型动物合格率、制备模型速度等方面具有一定的提高。该文就急性心肌梗死模型的制备方法及相关研究现状进行分析,结合实际因素以期简化模型制备过程,提高科研人员的造模水平,从而为医学研究提供稳定可靠的急性心肌梗死模型来源。
[Abstract]:Acute myocardial infarction is one of the major diseases that endanger human life. The pathophysiological changes of myocardial infarction animal model for the study of human myocardial infarction, has important significance in diagnosis and treatment of myocardial infarction. At present, the preparation of animal model mainly has low survival rate of animal, complex problem. In recent years, according to the model of myocardial infarction animal preparation the research methods have made some progress, the survival rate in animal model, animal model of qualified rate, has a certain improving preparation model speed and so on. This paper on the status of preparation method of acute myocardial infarction model and related research and analysis, combined with the actual factors in the preparation process of the simplified model system, improve the scientific research personnel level model thus, providing a source of acute myocardial infarction in a stable and reliable model for the study of medicine.

【作者单位】：中国中医科学院广安门医院;北京中医药大学;中国中医科学院西苑医院;
【基金】：国家自然科学基金资助项目(81173449)
【分类号】：R-332;R542.22

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