七氟烷和丙泊酚麻醉对老年肺癌患者的影响

发布时间：2018-04-10 03:27

本文选题：肺癌　切入点：七氟烷　出处：《中国老年学杂志》2015年14期

【摘要】：目的探讨七氟烷和丙泊酚麻醉对老年肺癌患者的影响。方法选取择期行肺癌根治术老年肺癌患者90例,随机数字表法分为观察组和对照组,每组45例。对照组给予丙泊酚麻醉,观察组给予七氟烷麻醉,对手术前后两组认知功能和血清S100β蛋白水平变化情况进行观察。结果术前1 d和术后7 d,两组患者认知功能MMSE评分均无明显差异(P0.05),术后6 h、术后1 d和术后3 d观察组认知功能MMSE评分逐渐升高,分别为(22.12±0.72)分、(25.20.±0.21)分、(26.02.±0.59)分,对照组为(20.31±0.6)分、(24.16±1.10)分、(25.48±0.57)分,组间差异显著(t=6.53、8.11、7.77,P0.05);术前30 min和术后30 min两组患者血清S100β蛋白水平均无明显差异(P0.05),术后1 d观察组血清S100β蛋白水平为(0.051±0.021)μg/L,明显低于对照组的(0.073±0.022)μg/L(t=5.62,P0.05)。结论七氟烷和丙泊酚麻醉均会对老年肺癌患者的认知功能产生一定的影响,但应用七氟烷麻醉,术后患者认知功能障碍的发生率较低且患者恢复更快。
[Abstract]:Objective to investigate the effect of sevoflurane and propofol anesthesia on elderly patients with lung cancer.Methods 90 elderly patients with lung cancer underwent radical resection of lung cancer were randomly divided into observation group (n = 45) and control group (n = 45).The control group was given propofol anesthesia and the observation group was given sevoflurane anesthesia. The changes of cognitive function and serum S100 尾 protein level before and after operation were observed.Results there was no significant difference in the MMSE scores of cognitive function between the two groups 1 day before operation and 7 days after operation. The MMSE scores of cognitive function in the observation group increased gradually at 6 hours, 1 day and 3 days after operation, which were 25.20.2 卤0.21 and 26.02 卤0.59, respectively.Conclusion both sevoflurane and propofol anesthesia can affect cognitive function in elderly patients with lung cancer, but the incidence of cognitive dysfunction is lower and patients recover more quickly after sevoflurane anesthesia.
【作者单位】：东莞市人民医院麻醉科;
【分类号】：R614

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