丙泊酚静脉麻醉对大鼠水杨酸钠排泄的影响

发布时间：2018-05-01 12:00

  本文选题：丙泊酚 + 血气分析　； 参考：《中国临床药理学杂志》2017年10期

【摘要】：目的研究丙泊酚全身麻醉过程对水杨酸钠排泄的影响及其机制。方法麻醉前,取雄性SD大鼠16只,腹腔注射1%水杨酸钠80 mg·kg~(-1)后,收集尿液,记录实际排尿时间和尿量。用光谱法测定尿液中水杨酸浓度,绘制尿药浓度-时间曲线。经3 d清洗期,上述大鼠尾静脉注射丙泊酚150 mg·kg~(-1)后,立即腹腔注射水杨酸钠,方法同前。绘制麻醉前与麻醉后尿药浓度-时间曲线,代入药代动力学分析软件3P97,计算尿药代动力学参数,比较麻醉前与麻醉后水杨酸钠排泄能力的变化。眶静脉丛取血检测血气指标,并进行血气指标与水杨酸累积排泄量相关分析。结果丙泊酚麻醉前与麻醉后,p H分别为7.44±0.04,7.37±0.06;二氧化碳分压(PCO2)分别为(39.58±6.42),(47.71±6.80)mm Hg;氧分压(PO2)分别为(88.25±6.80),(67.75±3.73)mm Hg;剩余碱(BE)分别为(1.20±1.05),(-5.08±1.88)mmol·L~(-1);最大排泄率(Rmax)分别为(0.62±0.15),(0.39±0.04)mg·h~(-1);Cmax分别为(1.43±0.23),(0.85±0.15)mg·kg~(-1);0~28 h排泄-时间曲线下面积(ERUC0-28)分别为(25.83±3.8),(17.35±2.01)mg·h·L~(-1),差异有统计学意义(均P0.05)。p H、PO2、BE与水杨酸累积排泄量呈明显正相关,相关系数(R2)分别为0.9758,0.9760,0.9398;而PCO2与水杨酸累积排泄量呈明显反正相关,R2为0.9023,差异有统计学意义(P0.05)。结论丙泊酚静脉麻醉能减慢大鼠水杨酸钠排泄速度,与血气指标显著相关。
[Abstract]:Objective to study the effect and mechanism of propofol general anesthesia on the excretion of sodium salicylate. Methods before anesthesia, 16 male Sprague-Dawley rats were injected intraperitoneally with 1% sodium salicylate (80 mg 路kg ~ (-1)). Urine was collected and the actual urination time and urine volume were recorded. The concentration of salicylic acid in urine was determined by spectral method. After 3 days of cleaning, sodium salicylate was injected intraperitoneally immediately after intravenous injection of propofol (150 mg 路kg ~ (-1)). The concentration-time curves of urinary drugs before and after anesthesia were drawn and the pharmacokinetic analysis software 3P97 was used to calculate the parameters of urinary pharmacokinetics and to compare the changes of excretion capacity of sodium salicylate before and after anesthesia. The blood gas index was measured in orbital venous plexus, and the correlation between blood gas index and accumulated salicylic acid excretion was analyzed. 缁撴灉涓欐硦閰氶夯閱夊墠涓庨夯閱夊悗,p H鍒嗗埆涓，

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