右美托咪定复合地佐辛用于面部整形手术麻醉的临床研究

发布时间：2018-05-08 05:27

本文选题：右美托咪定 + 地佐辛　；参考：《中国临床研究》2016年10期

【摘要】：目的探讨右美托咪定复合地佐辛在面部整形手术麻醉的应用效果,为临床麻醉方案的制定提供参考。方法选取2014年1月到2016年1月接受面部整形手术的患者104例,随机分为观察组和对照组各52例。对照组采用丙泊酚复合瑞芬太尼的静脉麻醉方案,观察组采用右美托咪定复合地佐辛的静脉麻醉方案。对比两组麻醉诱导前(T0)、麻醉诱导后(T1)、切皮时(T2)、术中(T3)、术后清醒时(T4)的平均动脉压(MAP)、心率(HR)、呼吸频率(RR)、血氧饱和度(Sp O2)以及脑电双频指数(BIS);对比两组的苏醒时间、清醒时间和不良反应发生情况。结果两组患者T1和T4的MAP、HR对比,差异均有统计学意义(P均0.05);T1、T2、T3、T4时观察组的RR、Sp O2显著高于对照组(P均0.05);观察组各个时间点的MAP、HR、RR、Sp O2以及BIS更为平稳;观察组的苏醒时间[(5.13±1.86)min vs(8.71±1.72)min,P0.05]和清醒时间[(6.98±1.73)min vs(10.73±2.08)min,P0.05]均少于对照组;观察组呼吸抑制及术后躁动的发生率均低于对照组,差异均有统计学意义(P均0.05)。结论右美托咪定复合地佐辛静脉麻醉用于面部整形手术的麻醉效果好,对患者血流动力学、呼吸功能的影响小,术后苏醒时间短,且不良反应少,是较为理想的麻醉方案。
[Abstract]:Objective to investigate the effect of dexmetomidine combined with dizosin in the anesthesia of facial plastic surgery. Methods 104 patients undergoing facial plastic surgery from January 2014 to January 2016 were randomly divided into observation group (n = 52) and control group (n = 52). Propofol combined with remifentanil was used in the control group and dexmetomidine combined with dizosin was used in the observation group. The mean arterial pressure (MAPP), heart rate (HRP), respiratory rate (RRN), blood oxygen saturation (SpO2) and bispectral index (BISI) were compared between the two groups before anesthesia induction, after anesthesia induction, during skin incision, during operation and awake after operation. Waking time and adverse reactions. Results the differences of MAPHR in T1 and T4 between the two groups were statistically significant (P < 0.05). The RRV SpO2 in the observation group was significantly higher than that in the control group (P < 0.05), and the MAPHR at each time point in the observation group was more stable than that in the control group (P < 0.05). The recovery time [5.13 卤1.86)min vs(8.71 卤1.72 min] and waking time (6.98 卤1.73)min vs(10.73 卤2.08 min P 0.05) in the observation group were lower than those in the control group, and the incidence of respiratory depression and postoperative restlessness in the observation group were lower than those in the control group (P < 0.05). Conclusion dexmetomidine combined with dizosin intravenous anesthesia is an ideal anaesthesia scheme for facial plastic surgery, with little effect on hemodynamics and respiratory function, short recovery time and less adverse reactions.
【作者单位】：西安交通大学第二附属医院麻醉科;兵器工业521医院麻醉科;解放军第四军医大学口腔医院麻醉科;
【分类号】：R614

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