肝癌动物模型与介入实验操作应用

发布时间：2018-05-16 01:34

本文选题：动物模型 + 动物实验　；参考：《介入放射学杂志》2017年11期

【摘要】：肝脏肿瘤治疗方法中,介入治疗的地位越来越重要。介入治疗发展取决于新材料、新设备、新药物的开发及应用,而这些应用的临床前动物实验是评价介入治疗安全性、有效性的重要一环。肝癌动物模型在介入治疗新方法探索中有着重要的先导作用。但目前适合介入治疗实验研究的肝癌动物模型很有限,主要局限于大鼠和兔。受动物体型限制,常规介入器械和设备不适用于介入操作,针对小鼠肝动脉内介入操作的器械尚缺乏,适用于大鼠介入操作器械也有限。本文就目前经肝动脉插管行介入治疗实验研究中经常选用的大鼠和兔肝癌模型类型、造模方法、介入操作、麻醉及影像学检查等应用进行总结。
[Abstract]:Interventional therapy is becoming more and more important in the treatment of liver tumors. The development of interventional therapy depends on the development and application of new materials, new equipment and new drugs. The preclinical animal experiments of these applications are important in evaluating the safety and effectiveness of interventional therapy. The animal model of liver cancer plays an important leading role in the exploration of new interventional therapy methods. However, the animal models suitable for interventional therapy are limited, mainly in rats and rabbits. Due to the limitation of animal body size, conventional interventional instruments and equipment are not suitable for interventional operation, but the instruments for interventional operation in mouse hepatic artery are still lacking, and are also limited for rats. In this paper, the types of rat and rabbit liver cancer models, the methods of modeling, interventional operation, anesthesia and imaging examination, which are often used in the experimental study of interventional therapy through hepatic artery catheterization, are summarized.
【作者单位】：解放军总医院介入放射科;
【基金】：国家自然科学基金面上项目(81671800) 北京市自然科学基金面上项目(7172204)
【分类号】：R735.7

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