TJ0711对自发性高血压和哇巴因-高血压麻醉大鼠的急性降压

发布时间：2018-05-18 09:28

本文选题：TJ + β受体阻断剂　；参考：《中国医院药学杂志》2015年21期

【摘要】：目的:观察新型肾上腺素α,β受体双重阻断剂TJ0711静脉注射对自发性高血压大鼠(SHR)和哇巴因-高血压大鼠(OHR)2种模型的急性降压作用。方法:制备OHR模型:SD大鼠连续8周腹腔注射30μg·kg-1·d-1哇巴因,将收缩压21.3 k Pa(1 k Pa≈7.5 mm Hg)者随机分为生理盐水(N.S)组、TJ0711 0.3,0.9,2.7 mg·kg-1剂量组、阳性对照卡维地洛1 mg·kg-1组(n=12);购得的SHR分组方法同OHR。用10%乌拉坦(1.3 g·kg-1,i.p)麻醉,仰位固定,分离一侧颈总动脉插管连接多通道生理记录仪测血压和心率,颈外静脉插管给药。观察给药前后大鼠收缩压、舒张压、心率的变化,分析TJ0711静注降压作用规律。结果:TJ0711静注给药后2~15 min即达到最大降压水平,降压作用维持25~75 min。对SHR和OHR两种高血压模型收缩压与舒张压下降趋势一致,但对SHR收缩压、舒张压最大降压幅度高于OHR。结论:TJ0711静脉注射能快速、短效降低SHR和OHR两高血压模型大鼠的血压同时使心率适当减慢,具有良好的急性降压特点。
[Abstract]:Objective: To observe the acute antihypertensive effect of a new type of adrenalin alpha and beta receptor double blocker TJ0711 on 2 models of spontaneously hypertensive rats (SHR) and ouabain hypertensive rats (OHR). Methods: to prepare a OHR model: SD rats were intraperitoneally injected with 30 u g. Kg-1. D-1 ouabain for 8 weeks, and the systolic pressure was 21.3 K Pa (1 K Pa 7.5). The machine was divided into two groups: normal saline (N.S) group, TJ0711 0.3,0.9,2.7 mg / kg-1 dose group, positive control carvedilol 1 mg kg-1 group (n=12). The SHR grouping method and OHR. were anaesthetized with 10% urantan (1.3 g kg-1), and the side cervical artery intubation was attached to the multichannel physiological recorder to measure blood pressure and heart rate, and the external jugular vein catheterization was given. The changes of systolic pressure, diastolic pressure and heart rate of rats before and after administration were observed. The results were as follows: 2~15 min reached the maximum depressor level after intravenous injection of TJ0711, and the antihypertensive effect maintained 25~75 min. on the decreasing trend of systolic pressure and diastolic pressure of two kinds of hypertension models of SHR and OHR, but the maximum decrease of systolic pressure and diastolic pressure on SHR systolic pressure. The pressure amplitude is higher than the OHR. conclusion: the intravenous injection of TJ0711 can quickly and effectively reduce the blood pressure of the rat model of SHR and OHR two, and the heart rate can be slowed down properly, and it has a good characteristic of acute hypotension.
【作者单位】：华中科技大学同济医学院药学院;
【基金】：国家“重大新药创制”科技重大专项(编号:2009ZX09103-146) 湖北省研究与开发计划项目(编号:2008BCB103)
【分类号】：R544.1

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