异丙酚联合盐酸戊乙奎醚在无痛人流中的麻醉效果观察

发布时间：2018-05-19 02:19

本文选题：长托宁 + 异丙酚　；参考：《中国继续医学教育》2016年31期

【摘要】：目的探讨异丙酚联合盐酸戊乙奎醚(长托宁)在无痛人流中的麻醉效果。方法选取2014年1月~2015年12月的80例需人流患者随机分为观察组与对照组,每组40例。观察组在静脉推注长托宁0.5 mg后1 min静脉注入异丙酚,再行人流手术;对照组仅给予静脉注入异丙酚后行人流手术,观察对比两组患者麻醉起效和苏醒时间、平均呼吸暂停时间、口腔分泌和呛咳反应情况、宫颈口松驰程度和心率的变化。结果观察组用药后平均呼吸暂停时间为(7.9±2.6)s;口腔分泌量(4.1±1.6)ml;出现呛咳反应0例;宫颈口松驰27例;用药前心率(73.2±6.4)次/分,用药后10 min心率(71.5±5.2)次/分,差异无统计学意义(t=1.303 8,P0.05);麻醉起效时间(3.5±0.8)min,苏醒时间(5.5±1.2)min。对照组用药后平均呼吸暂停时间为(37.1±4.3)s;口腔分泌量(12.4±2.3)ml;出现呛咳反应10例;宫颈口松驰5例;用药前心率(73.7±5.7)次/分,用药后10 min心率(66.2±6.1)次/分,差异有统计学意义(t=5.681 7,P0.05);麻醉起效时间(5.1±0.7)min,苏醒时间(6.5±1.4)min。上述观察指标组间对比,均存在统计学差异(P0.05)。结论异丙酚联合长托宁用于无痛人流能减少呼吸暂停时间,抑制口腔分泌,减少呛咳反应,改善宫颈口松驰度,抑制心率波动,提高无痛人流手术安全性,增强手术效果。
[Abstract]:Objective to investigate the anesthetic effect of propofol combined with penehyclidine hydrochloride in painless abortion. Methods from January 2014 to December 2015, 80 patients were randomly divided into observation group and control group with 40 cases in each group. In the observation group, propofol was injected intravenously 1 min after intravenous injection of Changtonin, and then the artificial abortion was performed in the control group. The time of onset and recovery of anesthesia was observed and compared between the two groups, and the patients in the control group were treated with propofol only after intravenous injection of propofol. Changes of mean apnea time, oral secretion and cough response, degree of relaxation of cervix and heart rate. Results the mean apnea time was 7.9 卤2.6 Ms, oral secretion was 4.1 卤1.6 ml, cough reaction occurred in 0 cases, cervix was relaxed in 27 cases, heart rate was 73.2 卤6.4 times / min before medication, and heart rate was 71.5 卤5.2 / min 10 min after medication. There was no significant difference in the onset time of anesthesia (3.5 卤0.8 min) and recovery time (5.5 卤1.2 min). In the control group, the mean apnea time was 37.1 卤4.3 Ms, oral secretion was 12.4 卤2.3 ml, choking reaction occurred in 10 cases, cervix was relaxed in 5 cases, heart rate was 73.7 卤5.7 times / min before treatment, and heart rate was 66.2 卤6.1 beats / min 10 min after medication. The difference was statistically significant (P 0.05), the onset time of anesthesia was 5.1 卤0.7 min, and the recovery time was 6.5 卤1.4 min. There was statistical difference between the two groups (P 0.05). Conclusion propofol combined with Changtuoning can reduce apnea time, inhibit oral secretion, reduce cough response, improve relaxation of cervix, inhibit heart rate fluctuation, improve the safety of painless artificial abortion, and enhance the effect of operation.
【作者单位】：江苏大学附属医院麻醉科;
【分类号】：R169.42

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