合谷穴区去感觉传入后恒河猴躯体感觉皮层的脑可塑性研究

发布时间：2018-05-29 16:09

本文选题：面口合谷收 + 感觉皮层　；参考：《广州中医药大学》2014年硕士论文

【摘要】：目的：观察合谷穴区去感觉传入后恒河猴躯体感觉皮层手区和面区的可塑性,探讨“面口合谷收”的生物学机制。方法：切断恒河猴正中神经和桡神经后,用针刺方式刺激麻醉状态下恒河猴的合谷穴区和面口部,记录躯体感觉皮层神经元的放电活动,并勾画其外周感受野,比较切断正中神经和桡神经前后外周感受野的变化。成果：在恒河猴躯体感觉皮层S1区共记录A到N共14个通道神经元的感受野。切断正中神经和桡神经前,通道A至E的神经元感受野为手部区域,通道F至N的神经元感受野均为面部。通道A的神经元感受野为手背侧拇指根部至指尖；通道B、D的神经元感受野均为手掌侧大鱼际；通道C的神经元感受野为手掌侧拇指、食指根部至指尖；通道E的神经元感受野为手掌侧拇指根部至指尖；通道F、G、H的神经元感受野均为面部左侧唇以下颏肌、降下唇肌覆盖的部位；通道K、Ⅰ的神经元感受野均为面部左侧鼻旁鼻肌、提上唇肌覆盖的区域；通道J、L的神经元感受野均为面部左侧颊肌、腮腺管覆盖区域；通道M、N的神经元感受野均为面部左侧咬肌、降口角肌、降下唇肌覆盖区域。正中神经和桡神经切断后1小时后,通道A、B、C、D、E、F的神经元对手部刺激不起反应,其余通道的感受野未发生变化。切断后7小时,通道A、B、C、D的神经元对手部刺激不起反应；通道E得神经元感受野为手掌侧拇指根部至指尖转变为面部左侧唇以下颏肌、降下唇肌覆盖的部位；其余通道的神经元感受野未发生变化。切断后24小时,通道A、B的神经元对手部刺激不起反应；通道C、D、E的神经元感受野均由切断前的区域转变为面部左侧唇以下颏肌、降下唇肌覆盖的部位；其余通道的感受野未发生变化。结论：合谷穴区去感觉传入后,躯体感觉皮层面区向手区进行了极小的扩张,手区和面区发生了重组,体表与体表的特定联系更加突出,与脑可塑性密切相关。这可能是病理状况下“面口合谷收”的生物学机制之一。
[Abstract]:Objective: To observe the plasticity of hand and facial regions of somatosensory cortex in rhesus monkey after sensory afferent in Hegu acupoint area, and to explore the biological mechanism of "face mouth and valley harvest". Methods: After the median nerve and radial nerve of rhesus monkey were cut off, the area of Hegu acupoint and the facial orifice of rhesus monkey under anesthesia were stimulated by acupuncture. The discharges of somatosensory cortical neurons were recorded, and the peripheral receptive fields were delineated. The changes of peripheral receptive field before and after transection of median nerve and radial nerve were compared. Outcome: A total of 14 channels were recorded in the S1 region of somatosensory cortex of rhesus monkeys. Before the median nerve and radial nerve were transected, the receptive field of channel A to E was the hand region, and that of channel F to N was facial. The neuronal receptive field of channel A was from the root of the dorsal thumb of the hand to the tip of the finger, the neuronal receptive field of channel BnD was the hypothenar side of the palm, and the neuronal receptive field of channel C was the thumb of the palm and the root of the forefinger to the tip of the finger. The neuronal receptive field of channel E is from the root of the palmar thumb to the fingertip, the neuronal receptive field of the channel FG H is the place covered by the lower chin muscle on the left lip of the face, and the neuronal receptive field of channel K, I are all the nasal muscles of the left side of the face. The area covered by the levator labium muscle, the area covered by the facial left buccal muscle and the parotid duct, and the area covered by the facial left masseter muscle, the descending horn muscle and the lower labial muscle were all the neuronal receptive fields of the channel Mnn were the left buccal muscle of the face and the parotid duct covered area. One hour after median nerve and radial nerve transection, the neurons of the channel Agna C ~ (2 +) D ~ (1) E _ (F) did not respond to the stimulation of the hand, but the other channels' receptive fields did not change. At 7 hours after transection, the neurons of channel Agna C ~ (2 +) could not respond to the stimulation of the hand, and the receptive field of channel E was the place where the palmar thumb was transformed from the root of the thumb to the tip of the finger to the left lip of the face to the chin muscle, which was covered by the labial muscle. There was no change in the sensory field of the other channels. At 24 hours after transection, the neurons of channel Aneb did not respond to the stimulation of the hand, and the receptive field of the neurons of channel CfU E changed from the region before the dissection to the part of the chin muscle on the left lip of the face, which was covered by the labial muscle. There was no change in the sensory field of the other channels. Conclusion: After the sensory afferent of the Hegu acupoint area, the somatosensory skin area expanded to the hand area, the hand area and the facial area were reorganized, and the specific connection between the body surface and the body surface was more prominent, which was closely related to the plasticity of the brain. This may be one of the biological mechanisms of facial constriction under pathological conditions.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R245

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