咪唑安定注射液联合地佐辛注射液对围术期胃肠道肿瘤患者的镇痛疗效研究

发布时间：2018-06-07 22:58

  本文选题：咪唑安定 + 地佐辛　； 参考：《中国临床药理学杂志》2017年01期

【摘要】：目的观察咪唑安定联合地佐辛对围术期胃肠道肿瘤患者的镇痛疗效及安全性。方法将74例胃肠道肿瘤患者随机分为对照组37例与试验组37例。对照组予以静脉注射咪唑安定0.06 mg·kg~(-1)+芬太尼1.0μg·kg~(-1);试验组予以静脉注射咪唑安定0.06 mg·kg~(-1)+地佐辛0.1 mg·kg~(-1)。麻醉效果满意后,由同一医师完成胃肠道肿瘤根治术。比较2组患者的免疫功能、炎性因子,以及药物不良反应的发生情况。结果术后4 h,试验组和对照组的NK细胞百分比分别为(14.39±2.28)%,(12.99±1.84)%;CD_3~+分别为(52.94±4.19)%,(48.15±4.36)%;CD_4~+分别为(27.64±2.15)%,(24.71±2.08)%;CD_4~+/CD_8~+分别为(1.04±0.12),(0.96±0.15);白细胞介素-2(IL-2)分别为(72.92±8.32),(65.71±8.25)pg·mL~(-1);C反应蛋白分别为(48.26±9.14),(83.91±11.96)mg·L-1;肿瘤坏死因子-α分别为(26.81±6.30),(29.94±5.71)pg·mL~(-1);IL-6分别为(45.31±5.08),(66.95±7.13)pg·mL~(-1),差异均有统计学意义(P0.05)。试验组和对照组轻度不适分别为8.11%(3/37例),27.03%(10/37例);呼吸抑制分别为10.81%(4/37例),62.16%(23/37例);恶心呕吐发生率分别为5.41%(2/37例),35.14%(13/37例),差异均有统计学意义(P0.05)。试验组和对照组完全性遗忘发生率分别为78.38%(29/37例),83.78%(31/37例),差异无统计学意义(P0.05)。结论咪唑安定联合地佐辛方案与咪唑安定联合芬太尼方案对围术期胃肠道肿瘤患者的镇痛疗效相当,但前者能有效地促进患者术后免疫功能的恢复,控制炎症反应,且安全性较好。
[Abstract]:Objective to observe the analgesic efficacy and safety of midazolam combined with dizosin in patients with gastrointestinal cancer during perioperative period. Methods 74 patients with gastrointestinal cancer were randomly divided into control group (n = 37) and trial group (n = 37). The control group was given intravenous injection of midazolam 0.06 mg / kg, fentanyl 1.0 渭 g / kg, and the experimental group was given 0.06 mg / kg / kg of midazolam and 0.1 mg / kg / kg of dizoxin, respectively. After the anesthetic effect was satisfied, the same doctor completed the radical operation of gastrointestinal cancer. The immune function, inflammatory factors and adverse drug reactions were compared between the two groups. 缁撴灉鏈�鍚�4 h,璇曢獙缁勫拰瀵圭収缁勭殑NK缁嗚優鐧惧垎姣斿垎鍒�涓�(14.39卤2.28)%,(12.99卤1.84)%;CD_3~ 鍒嗗埆涓，

本文编号：1993161