右美托咪定在儿科临床镇静的应用现状

发布时间：2018-06-23 14:13

  本文选题：右美托咪定 + 儿科　； 参考：《中国医院药学杂志》2017年09期

【摘要】：儿童检查前及术前常需要应用镇静药物使操作顺利进行。许多临床常用的麻醉镇静剂在动物研究中,被发现具有神经毒副作用;对于某些镇静药物,在应用过程中可能会产生呼吸抑制作用,这些不良反应对处于发育期的儿童是不可忽视的。右美托咪定(dexmedetomidine,DEX)是一种高选择性α2-肾上腺素受体激动剂,具有镇静及镇痛作用。通过检索国内外DEX在儿童镇静中的应用,结果显示,DEX引发并维持自然非动眼睡眠状态,产生镇静、催眠作用,镇静过程中无呼吸抑制作用,为安全有效的镇静药物。虽然DEX在我国未被推荐用于儿科镇静,但是它的应用越来越受到广大麻醉医生及药师的关注,DEX临床研究可能为儿科临床镇静提供更好的选择。
[Abstract]:Children often need to use sedatives before and before examination to make the operation smooth. Many commonly used anesthetic sedatives have been found to have neurotoxic side effects in animal studies; for certain sedatives, respiratory inhibition may occur during the use of certain sedatives. These adverse reactions can not be ignored in children in the developmental stage. Dexmedetomidine (DEX) is a highly selective 伪 2 adrenergic receptor agonist with sedative and analgesic effects. By searching for the application of DEX in children sedation at home and abroad, the results showed that DEX induced and maintained the state of natural immobility sleep, produced sedation, hypnosis and no respiratory inhibition during sedation, so it was a safe and effective sedative. Although DEX is not recommended for pediatric sedation in China, its application has attracted more and more attention of anesthesiologists and pharmacists. The clinical study of DEX may provide a better choice for pediatric clinical sedation.
【作者单位】： 吉林大学第一医院药学部;
【分类号】：R726.1
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本文编号：2057392