潜阳育阴颗粒对正常麻醉犬肾动脉血流量及血压的影响

发布时间：2018-07-07 16:30

本文选题：潜阳育阴颗粒 + 麻醉犬　；参考：《南京中医药大学学报》2015年02期

【摘要】：目的观察潜阳育阴颗粒对正常麻醉犬肾动脉血流量及血压的影响,初步探讨其治疗高血压肾损害的作用机制。方法应用Power Lab系统记录给予潜阳育阴颗粒低、中、高剂量(3.08、6.15、12.30 g/kg)后0~180 min内不同时段比格犬肾动脉血流量、心输出量和血压的变化。结果潜阳育阴颗粒高剂量组给药后120、180 min动脉收缩压(SBP)显著降低(P0.05),给药后90、120、180 min,肾血流量显著升高(P0.05);潜阳育阴颗粒中剂量组给药后120 min,SBP明显下降(P0.05),给药后90、120 min,肾血流量明显升高(P0.05);低剂量组给药后180 min内各项指标变化不明显。潜阳育阴颗粒3个剂量组心输出量(CO)均未见明显变化。结论潜阳育阴颗粒主要通过增加肾动脉血流量,保护肾功能,从而降低血压。
[Abstract]:Objective to observe the effect of Qianyang Yuyin granule on renal arterial blood flow and blood pressure in anesthetized dogs and to explore the mechanism of its treatment of hypertensive renal damage. Methods Power Lab system was used to record the changes of renal arterial blood flow, cardiac output and blood pressure of Beagle dogs at different time periods within 0 ~ 180 min after treatment with Qianyang Yuyin granules at low, medium and high doses (3.08 ~ 6.150.30 g/kg). Results in the high dose group of Qianyang Yuyin granule, the systolic blood pressure (SBP) decreased significantly at 120180 min (P0.05), and the renal blood flow increased significantly (P0.05) at 90120180 minutes after administration, while in the middle dose group of Qianyang Yuyin granule, the SBP decreased significantly (P0.05), and 90120 minutes after administration, the renal blood flow was significantly decreased (P0.05). The dosage was significantly increased (P0.05), and the changes of the indexes within 180 min were not obvious in the low dose group. The cardiac output (CO) of Qianyang Yuyin granules did not change significantly in all three dose groups. Conclusion Qianyang Yuyin granule can decrease blood pressure by increasing renal arterial blood flow and protecting renal function.
【作者单位】：南京中医药大学药学院;南京中医药大学附属医院;南京中医药大学药物安全评价研究中心;
【基金】：江苏省中医药管理局2011专项补助基金
【分类号】：R285.5

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