比较三种丙泊酚制剂对高脂血症患者围术期血脂水平的影响

发布时间：2018-07-12 20:15

本文选题：高脂血症 + 丙泊酚　；参考：《临床麻醉学杂志》2015年04期

【摘要】：目的比较三种丙泊酚制剂对高脂血症患者围术期血脂水平的影响。方法选择择期手术高脂血症患者80例,随机均分为四组,每组20例。A组和B组分别使用不同厂家的丙泊酚中长链脂肪乳(规格20ml/200mg),C组使用另一厂家的丙泊酚长链脂肪乳(规格50ml/500mg),D组吸入七氟醚维持全麻。分别在麻醉诱导前(T0)、手术结束时(T1)、手术结束后1h(T2)和术后24h(T3)抽取静脉血,检测总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清淀粉酶(AMY)含量。结果四组完成例数:A组19例,B组17例,C组18例,D组19例。与T0时比较,A、B、C组在T1时TC值明显下降(P0.05),且A、C组下降更明显(P0.01);与D组比较,C组在T1、T2时TC值明显降低(P0.05)。与T0时比较,A、B、C组在T3时TG值明显降低(P0.05),B、C组下降更明显(P0.01)。与T0时比较,C组在T3时HDL明显升高(P0.05)。与T0时比较,A、B、C组在T1时LDL值明显下降(P0.05),C组下降更明显(P0.01);与D组比较,C组在T1、T2时LDL值明显降低(P0.01)。与D组比较,A组在T3时ALT、AST值明显升高(P0.05)。与T0时比较,A、B、C组在T2、T3时AMY值明显升高(P0.05);与D组比较,A、B、C组在T3时AMY值明显升高(P0.05),C组升高更明显(P0.01)。结论丙泊酚长链脂肪乳对高脂血症患者血脂的影响较中长链脂肪乳小,更适合用于高脂血症患者全身麻醉。
[Abstract]:Objective to compare the effect of three propofol preparations on blood lipid levels in patients with hyperlipidemia. Methods 80 patients with hyperlipidemia were randomly divided into four groups. 20 patients in group A and group B were treated with propofol medium chain fat emulsion (20ml/200mg) from different manufacturers and group C with propofol long chain fat emulsion (50ml/500mg) from another manufacturer. Group D inhaled sevoflurane to maintain general anesthesia. Venous blood was taken before anesthesia induction (T0), at the end of operation (T1), 1 hour after operation (T2) and 24 hours after operation (T3), respectively. Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), alanine aminotransferase (alt), aspartate aminotransferase (AST) and serum amylase (Amy) were measured. Results there were 19 cases in group A, 17 cases in group B, 18 cases in group C, 19 cases in group D. Compared with T0, the TC value of AZB group was significantly decreased at T1 (P0.05), and that of ANAC group was more significant (P0.01), and TC value of T1T 2 group was significantly lower than that of D group (P0.05). Compared with T0, the TG value of ANABU C group was significantly lower at T3 (P0.05) than that of T0 group (P0.01). Compared with T 0, HDL in C group was significantly higher than that at T 3 (P 0.05). Compared with T0 group, the LDL value of Agna BU C group was significantly lower at T1 (P0.05) than that of C group (P0.01), and that of C group was significantly lower than that of D group (P0.01) at T 1 and T 2 (P0.01). Compared with group D, AST in group A was significantly higher than that in group D (P 0.05). Compared with T0, the Amy value in T2T3-group was significantly higher than that in T0 group (P0.05), and the value of Amy in group D was significantly higher than that in group D (P0.05). The increase of Amy value in group C was more obvious than that in group D (P0.01). Conclusion the effect of propofol long chain fat emulsion on blood lipid in patients with hyperlipidemia is smaller than that in medium long chain fat milk, and it is more suitable for general anesthesia in patients with hyperlipidemia.
【作者单位】：南京大学医学院研究生院;解放军第八一医院麻醉科;
【分类号】：R614

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