厚朴酚与和厚朴酚在大鼠不同肠道中的吸收情况及与药物浓度关系

发布时间：2018-07-13 11:59

【摘要】：目的:研究厚朴酚与和厚朴酚在大鼠肠道中不同部位的吸收情况及与药物浓度的关系。方法:取雄性健康Wistar大鼠麻醉后建立在体单向肠灌流模型,采用HPLC测定厚朴提取物中厚朴酚与和厚朴酚在大鼠十二指肠、空肠、回肠和结肠浓度变化,计算厚朴酚与和厚朴酚在各肠段的吸收速率常数(Ka)、表观吸收系数(Papp)和吸收百分率(AR)来研究厚朴酚与和厚朴酚的吸收动力学特征。结果:厚朴提取物中厚朴酚与和厚朴酚在大鼠十二指肠、空肠、回肠和结肠的Ka、Papp和AR差异具有统计学意义(P0.01),均为十二指肠空肠回肠结肠;不同浓度厚朴提取物中的厚朴酚与和厚朴酚在同一肠段的Ka、Papp和ARp差异无统计学意义(P0.05)。结论:厚朴提取物中厚朴酚与和厚朴酚在大鼠肠道上段的吸收效果更好,越往肠下端吸收越差,且与提取物浓度无直接关系,其吸收机制可能为被动转移。
[Abstract]:Aim: to study the absorption of honokiol and honokiol in different parts of rat intestine and their relationship with drug concentration. Methods: the unilateral intestinal perfusion model was established after anesthesia in male healthy Wistar rats. The concentrations of honokiol and honokiol in duodenum jejunum ileum and colon of rats were determined by HPLC. The absorption rate constant (Ka), apparent absorption coefficient (Papp) and absorption percentage (AR) of honokiol and honokiol in various intestinal segments were calculated to study the absorption kinetics of honokiol and honokiol. Results: there were significant differences between magnolol and honokiol in the duodenum, jejunum, ileum and colon of rats (P0.01). There was no significant difference between Magnolol and Magnolol in different concentrations of Magnolia officinalis extract in the same intestinal segment (P0.05). Conclusion: the absorption of honokiol and honokiol in the extract of Magnolia officinalis is better than that in the upper part of the intestine of rats. The absorption of honokiol and honokiol in the extract of Magnolia officinalis is worse than that in the lower part of intestine, and it has no direct relation with the concentration of the extract.
【作者单位】：山西医科大学药学院;山西长治医学院附属和平医院;山西医科大学第一临床医院;
【分类号】：R285.5

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