小剂量右美托咪定在老年高血压患者围麻醉期控制血压的疗效及安全性

发布时间：2018-08-09 09:33

【摘要】：目的观察小剂量右美托咪定对老年高血压患者在手术围麻醉期对血压临床控制效果。方法 96例行手术治疗的老年高血压患者,按入院时间分为治疗组与对照组,每组48例。治疗组静脉泵注小剂量右美托咪定,对照组静脉滴注氟化钠溶液,观察两组患者的心率、血压、血氧饱和度及不良反应发生情况。结果给药前两组收缩压、心率、血氧饱和度比较差异无统计学意义(P0.05),给药后对照组较治疗组收缩压、心率波动大(P0.05);两组血氧饱和度比较差异无统计学意义(P0.05)。服药后治疗组恶心呕吐、呼吸抑制、寒战不良反应发生情况分别为2.1%、0、2.1%较对照组的12.5%、8.3%、12.5%少(P0.05),两组心动过缓情况比较差异无统计学意义(P0.05)。结论临床使用小剂量右美托咪定可有效控制老年高血压患者在手术围麻醉期的血压,达到降低血压、心率目的 ,且用药安全。
[Abstract]:Objective to observe the effect of low dose dexmetomidine on blood pressure control in elderly patients with hypertension during perioperative anesthesia. Methods 96 elderly patients with hypertension were divided into treatment group (n = 48) and control group (n = 48). The heart rate, blood pressure, blood oxygen saturation and adverse reactions were observed in the treatment group and the control group respectively. Results there was no significant difference in systolic blood pressure, heart rate and oxygen saturation between the two groups before administration (P0.05), but there was no significant difference in systolic blood pressure and heart rate fluctuation between the control group and the treatment group (P0.05). The incidence of nausea and vomiting, respiratory inhibition and shivering adverse reactions in the treatment group were 2.1% and 12.5% respectively (P0.05), and there was no significant difference in bradycardia between the two groups (P0.05). Conclusion low dose dexmetidine can effectively control the blood pressure of the elderly patients with hypertension during perianaesthesia period, achieve the purpose of lowering blood pressure and heart rate, and it is safe to use drugs.
【作者单位】：辽宁省本溪市本钢总医院麻醉科;
【分类号】：R614

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