腰椎手术静-吸复合麻醉脑电双频指数为50时的丙泊酚半数有效血浆靶浓度

发布时间：2018-08-13 21:03

【摘要】：目的观察腰椎手术静-吸复合麻醉脑电双频指数(BIS)维持50时丙泊酚半数有效血浆靶浓度(Cp50)。方法择期行腰椎间盘髓核摘除术患者,年龄40~56岁,术中麻醉维持采用吸入0.5 MAC七氟醚、静脉泵注瑞芬太尼0.2μg·kg~(-1)·min~(-1)和维库溴铵0.08mg·kg~(-1)·h~(-1),同时TCI丙泊酚。采用序贯法确定丙泊酚靶浓度,初始血浆靶浓度为1.8μg/ml,相邻浓度比为1∶1.1;若患者术中平均BIS值50,则下一例患者靶浓度为1.98μg/ml;若BIS≤50,则下一例患者靶浓度为1.64μg/ml,以此类推。计算丙泊酚Cp50及其95%可信区间(CI)。结果共有26例患者完成序贯试验。丙泊酚Cp50为1.61μg/ml(95%CI 1.52~1.70)μg/ml。结论腰椎手术中0.5 MAC七氟醚复合瑞芬太尼及TCI丙泊酚麻醉,术中维持BIS值为50时所需丙泊酚的Cp50为1.61μg/ml。
[Abstract]:Objective to observe the mean effective plasma target concentration (Cp50) of propofol at the maintenance of bispectral index (BIS) for intravenous and inhaling anesthesia of lumbar spine. Methods selective lumbar discectomy was performed for 40 to 56 years old. Anesthesia was maintained by inhalation of 0.5 MAC sevoflurane, intravenous infusion of remifentanil 0.2 渭 g kg-1, vecuronium 0.08mg kg-1 h-1, and TCI propofol. The target concentration of propofol was determined by sequential method, the initial target concentration of propofol was 1.8 渭 g / ml, the ratio of adjacent concentration was 1: 1.1; if the average intraoperative BIS value was 50, the target concentration of the next patient was 1.98 渭 g / ml; if BIS 鈮，

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