右美托咪定与咪达唑仑治疗胸科老年人麻醉术后谵妄的效果比较

发布时间：2018-09-10 09:06

【摘要】：目的探讨右美托咪定与咪达唑仑(力月西)在胸科老年人麻醉术后谵妄的临床效果。方法将76例胸外科老年手术患者随机分为观察组和对照组各38例,两组均给予芬太尼持续静脉泵入镇痛,对照组首次静脉推注力月西0.05mg/kg,随后以0.02~0.08 mg·kg~(-1)·h~(-1)维持麻醉,观察组首次静脉推注右美托咪定1.0μg/kg,然后以0.2~0.7μg·kg~(-1)·h~(-1)维持麻醉,比较两组镇静效果和不良反应发生。结果两组镇静效果时间均无统计学差异(P0.05);但观察组停药后苏醒时间短于对照组,不良反应发生率低于对照组(P0.05)。两组手术后SDS及SAS评分明显低于干预前,且观察组明显低于对照组(P0.05)。结论右美托咪定用于胸外科老年手术中的镇静效果好,且降低不良反应发生率。
[Abstract]:Objective to investigate the clinical effect of dexmetomidine and midazolam on delirium after thoracic anesthesia in the elderly. Methods Seventy-six elderly patients undergoing thoracic surgery were randomly divided into observation group (n = 38) and control group (n = 38). Fentanyl was administered with continuous intravenous infusion of fentanyl in both groups. The control group received intravenous injection of 0.05 mg / kg for the first time, and then maintained anesthesia with 0.02g / kg 0.08 mg kg~ (-1) h ~ (-1). In the observation group, dexmetomidine was given intravenously for the first time, and then maintained with 0.2 渭 g kg~ (-1) h-1. The sedation effect and adverse reactions were compared between the two groups. Results there was no significant difference in sedation time between the two groups (P0.05), but the recovery time of the observation group was shorter than that of the control group, and the incidence of adverse reactions was lower than that of the control group (P0.05). The scores of SDS and SAS in the two groups after operation were significantly lower than those before intervention, and those in the observation group were significantly lower than those in the control group (P0.05). Conclusion the sedative effect of dexmetomidine in elderly thoracic surgery is good and the incidence of adverse reactions is decreased.
【作者单位】：中航工业成都三六三医院;
【基金】：国家科技支撑计划(2012BAK21B01-02-2)
【分类号】：R614

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