益气活血风静胶囊对麻醉犬脑血流量和脑血管阻力的影响

发布时间：2018-09-19 14:04

【摘要】：目的:研究益气活血风静胶囊对麻醉犬脑血流量(CBF)及脑血管阻力(CVR)的影响,为其临床应用提供药理学依据。方法:将18只Beagle犬随机分为假手术组(纯化水)、阳性对照中药组[脑心通胶囊,0.3 g(生药)/kg]、阳性对照化学药组(尼莫地平,7×10~(-3)g/kg)和益气活血风静胶囊高、中、低剂量组[2.52、1.26、0.63 g(生药)/kg)],每组3只。犬麻醉后十二指肠给药,分别于给药前和给药30、60、120 min后测定血压、心率和CBF、CVR的变化。结果:给药30、60、120 min后,阳性对照中药组、阳性对照化学药组和益气活血风静胶囊高剂量组犬CBF明显增加,阳性对照化学药组和益气活血风静胶囊高剂量组犬CVR明显减小,阳性对照化学药组犬血压和心率降低,与假手术组比较差异均有统计学意义(P0.05或P0.01)。结论:益气活血风静胶囊可减小麻醉犬CVR、增加CBF,对血压及心率无影响。
[Abstract]:Objective: to study the effects of Yiqi Huoxue Fengjing capsule on cerebral blood flow (CBF) and cerebrovascular resistance (CVR) in anesthetized dogs. Methods: eighteen Beagle dogs were randomly divided into sham operation group (purified water), positive control group [Naoxintong capsule 0.3 g (crude drug) / kg], positive control chemical group (nimodipine 7 脳 10 ~ (-3) g/kg) and Yiqi Huoxue Jing capsule Gao, middle. Low dose group [2.52 (1.26) 0.63 g (crude drug) / kg], 3 rats in each group. After anesthesia, the changes of blood pressure, heart rate and CBF,CVR were measured before and after 30 minutes. Results: the CBF of the dogs in the positive control group, the positive control group and the high dose group of Yiqi Huoxue Fengjing capsule increased significantly after 30 ~ 60120 min, while the CVR in the positive control group and the high dose group of Yiqi Huoxue Fengjing capsule decreased significantly. The blood pressure and heart rate in the positive control group were significantly lower than those in the sham operation group (P0.05 or P0.01). Conclusion: Yiqi Huoxue Fengjing capsule can reduce the effect of CVR, on blood pressure and heart rate in anesthetized dogs.
【作者单位】：河南省食品药品检验所;
【基金】：河南省科技创新人才计划项目(No.144200510028)
【分类号】：R285.5

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