预注苯磺顺阿曲库铵对舒芬太尼诱发咳嗽的影响

发布时间：2018-10-15 13:16

【摘要】：目的评价麻醉诱导前静脉预注苯磺顺阿曲库铵对舒芬太尼诱发咳嗽(SFIC)的抑制效果。方法 200例气管插管全麻患者随机分为2组,每组各100例。对照组静脉注射0.9%Na Cl 1 m L,苯磺顺阿曲库铵预处理组注射苯磺顺阿曲库铵0.01 mg·kg-1。2组均于5 min后静脉注射舒芬太尼0.4μg·kg-1,注射时间2 s。记录2组患者咳嗽发生次数和时间,并根据咳嗽次数进行严重程度分级。分别于注射0.9%Na Cl或苯磺顺阿曲库铵时、注射舒芬太尼时及注射后1,2 min记录患者血压、心率、呼吸、脉搏血氧饱和度及药物不良反应。结果苯磺顺阿曲库铵预处理组SFIC的发生率(11.0%)明显低于对照组(35.0%)(P0.05);舒芬太尼诱发中度和重度咳嗽4例次(占36.4%),明显少于对照组的25例次(占71.4%)(P0.05)。2组咳嗽发生时间、血压及心率比较,差异无统计学意义。结论苯磺顺阿曲库铵预处理能有效降低SFIC的发生率和强度。
[Abstract]:Objective to evaluate the inhibitory effect of pre-intravenous injection of sulfentanil on cough (SFIC) induced by sufentanil before anesthesia induction. Methods 200 patients with tracheal intubation under general anesthesia were randomly divided into two groups, 100 cases in each group. In the control group, 0.9%Na Cl 1 mL was injected intravenously, and in the pretreatment group, the sufentanil 0.4 渭 g kg-1, was injected intravenously for 2 s in the pretreatment group and the control group was injected with sulfentanil 0. 4 渭 g kg-1, 5 min later. The number and time of cough were recorded and classified according to the number of cough. Blood pressure, heart rate, respiration, pulse oxygen saturation and adverse drug reactions were recorded at the time of injection of 0.9%Na Cl or sulfoxide, sufentanil injection and 1 ~ 2 min after injection. Results the incidence of SFIC was significantly lower (11.0%) in the benzenesulfonate cisatracurium preconditioning group than that in the control group (35.0%) (P0.05), and 4 moderate and severe cough induced by sufentanil (36.4%), which was significantly lower than that in the control group (25 cases, 71.4%) (P0.05). The difference was not statistically significant. Conclusion Pretreatment with benzenesulfonate atracurium can effectively reduce the incidence and intensity of SFIC.
【作者单位】：绍兴市人民医院麻醉科;
【基金】：浙江省医学会临床科研基金资助项目(2011ZYC-A88)
【分类号】：R614

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