不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响

发布时间：2018-10-17 20:25

【摘要】：目的探讨不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和白细胞介素2(IL-2)水平的影响。方法选取2013年1月-2016年12月该院行卵巢癌根治术的160例患者作为研究对象,根据随机数字法分为全身麻醉组和硬膜外麻醉组,每组80例。测量两组患者的外周血T淋巴细胞亚群含量及其相关细胞因子IL-2水平。结果全身麻醉组与硬膜外麻醉组患者年龄、体重、手术时间、术中出血量、输液量比较,差异无统计学意义(P0.05)。不同时间的CD3~+、CD4~+、CD4~+/CD8~+水平有差异(P0.05);全身麻醉组的CD3~+、CD4~+、CD4~+/CD8~+水平低于硬膜外麻醉组(P0.05);全身麻醉组和硬膜外麻醉组的CD3~+、CD4~+、CD4~+/CD8~+变化趋势有差异(P0.05)。不同时间的IL-2水平有差异(P0.05);全身麻醉组的IL-2水平低于硬膜外麻醉组(P0.05);全身麻醉组和硬膜外麻醉组的IL-2水平变化趋势有差异(P0.05)。结论硬膜外麻醉可减轻其对卵巢癌根治术患者围手术期细胞免疫功能的抑制作用。
[Abstract]:Objective to investigate the effects of different anesthetic methods on T lymphocyte subsets and interleukin 2 (IL-2) levels in patients with ovarian cancer during perioperative period. Methods from January 2013 to December 2016, 160 patients with ovarian cancer were divided into general anesthesia group (n = 80) and epidural anesthesia group (n = 80). The levels of T lymphocyte subsets and their cytokines IL-2 were measured in both groups. Results there was no significant difference between general anesthesia group and epidural anesthesia group in age, body weight, operation time, intraoperative blood loss and infusion volume (P0.05). The levels of CD3~, CD4~, CD4~ / CD8~ in general anesthesia group were lower than those in epidural anesthesia group (P0.05); CD3~, CD4~, CD4~ / CD8~ in general anesthesia group and epidural anesthesia group were different (P0.05). There were differences in IL-2 level at different time points (P0.05); IL-2 level in general anesthesia group was lower than that in epidural anesthesia group (P0.05); IL-2 level in general anesthesia group and epidural anesthesia group was different (P0.05). Conclusion epidural anesthesia can reduce the effect of epidural anesthesia on the perioperative cellular immune function in patients with ovarian cancer.
【作者单位】：浙江省临海市第一人民医院麻醉科;
【分类号】：R614;R737.31

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