右美托咪定在高血压患者脑动脉瘤栓塞术中的应用

发布时间：2018-11-08 17:46

【摘要】：目的研究右美托咪定应用于高血压患者脑动脉瘤栓塞术中的麻醉效果。方法选择60例急诊行脑动脉瘤栓塞术患者,均合并高血压,随机分为研究组(右美托咪定组)和对照组,每组30例。观察并记录患者入室时(T_0)、气管插管前(T_1)、气管插管后即刻(T_2)、气管导管拔除后即刻(T_3)的收缩压(SBP)、舒张压(DBP)、心率(HR)和血浆去甲肾上腺素(NE)浓度;记录两组患者拔管时间和不良反应发生率。结果研究组患者的血流动力学指标和NE在围术期不同时间点较对照组更加平稳,差异均有统计学意义(P0.05);拔管时间两组无明显差异(P0.05);研究组拔管后呛咳、烦躁的发生率低于对照组,差异有统计学意义(P0.05)。结论右美托咪定应用在合并有高血压的脑动脉瘤栓塞术患者中麻醉效果良好,可减少气管插管和拔除气管导管时的应激反应,使患者血流动力学更平稳,降低术后患者不良反应发生率。
[Abstract]:Objective to study the anesthetic effect of dexmetomidine on cerebral aneurysm embolization in hypertensive patients. Methods 60 patients with acute cerebral aneurysm embolization were randomly divided into study group (dexmetomidine group) and control group (30 cases in each group). The systolic pressure (SBP),) diastolic pressure (DBP),) was observed and recorded at the time of entering, before tracheal intubation, immediately after tracheal intubation (T _ 2), and immediately after tracheal catheter extubation (T _ 3). Heart rate (HR) and plasma norepinephrine (NE) concentration; The time of extubation and the incidence of adverse reactions were recorded in both groups. Results the hemodynamic indexes and NE in the study group were more stable than those in the control group at different time points during perioperative period (P0.05), but there was no significant difference in the extubation time between the two groups (P0.05). The incidence of cough and irritability after extubation in the study group was lower than that in the control group (P0.05). Conclusion dexmetidine is effective in treating patients with hypertensive cerebral aneurysm embolization. It can reduce the stress reaction during tracheal intubation and extubation, and make hemodynamics more stable. Reduce the incidence of postoperative adverse reactions.
【作者单位】：暨南大学第二临床医学院深圳市人民医院麻醉科;
【分类号】：R614

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