呼气末正压通气对高原红细胞增多症患者全身麻醉围术期动脉血氧合的影响
发布时间:2018-11-23 11:32
【摘要】:目的观察呼气末正压通气(PEEP)对高原红细胞增多症(HAPC)患者全身麻醉围手术期动脉血氧合及麻醉苏醒的影响。方法选取择期行开腹胆囊切除术HAPC患者50例,年龄41~52岁,ASAⅠ、Ⅱ级,均无呼吸及循环系统合并症。两组患者均来自高原世居人群,随机分为A、B两组,各25例。A组手术开始即给予5 cm H2O PEEP,B组无PEEP。麻醉方式为全静脉插管全身麻醉,丙泊酚复合舒芬太尼及维库溴胺诱导,丙泊酚和瑞芬太尼靶控输注(TCL),50%氧空混合机械通气。采取两组患者手术切皮前(T1)、手术开始后15 min(T2)及手术结束前(T3)的动脉血样本,观察3个时间点的动脉血氧分压(Pa O2)、动脉血氧饱和度(Sa O2)、平均动脉压(MAP)、心率(HR);观察两组患者停药后的复苏时间。结果 A组患者T1与T2、T1与T3两时间点Pa O2、Sa O2组内相比差异均有统计学意义(P0.05);T2与T3两时间点Pa O2、Sa O2组内相比差异无统计学意义(P0.05);两组患者在T2和T3时间点Pa O2、Sa O2组间相比差异均有统计学意义(P0.05)。两组患者在T1、T2和T33个时间点MAP、HR组间比较差异无统计学意义(P0.05);A组和B组停药后的苏醒时间相比差异有统计学意义(P0.05)。结论 HAPC患者全身麻醉期间应用PEEP可有效促进肺通气及弥散功能,提高动脉氧合,减少麻醉苏醒时间,对循环影响小。
[Abstract]:Objective to observe the effect of positive end-expiratory pressure ventilation (PEEP) on arterial oxygenation and anaesthesia recovery in patients with high altitude polycythemia (HAPC) during general anesthesia perioperative period. Methods A total of 50 patients with HAPC undergoing open cholecystectomy, aged 41 to 52 years, were selected for elective cholecystectomy. There were no respiratory and circulatory complications in 50 patients with grade ASA 鈪,
本文编号:2351450
[Abstract]:Objective to observe the effect of positive end-expiratory pressure ventilation (PEEP) on arterial oxygenation and anaesthesia recovery in patients with high altitude polycythemia (HAPC) during general anesthesia perioperative period. Methods A total of 50 patients with HAPC undergoing open cholecystectomy, aged 41 to 52 years, were selected for elective cholecystectomy. There were no respiratory and circulatory complications in 50 patients with grade ASA 鈪,
本文编号:2351450
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