不同剂量地佐辛对乳腺癌根治术患者术后细胞免疫功能和细胞因子的影响

发布时间：2019-02-09 16:10

【摘要】：目的:观察不同剂量地佐辛对乳腺癌根治术患者术后T淋巴细胞亚群、NK细胞和IL-2和IL-10的浓度的影响。方法:40例乳腺癌根治术患者随机分为D1组和D2组,每组20例。麻醉诱导静注地佐辛0.2 mg/kg,术后患者静脉自控镇痛(PCIA)用地佐辛0.5 mg/kg(D1组)或0.8 mg/kg(D2组)。记录术后VAS评分,于麻醉前(T0)、术毕(T1)、术后1(T2)、3(T3)、7 d(T4)抽血检测T淋巴细胞亚群(CD3+、CD4+、CD8+水平以及CD4+/CD8+比值)和NK细胞水平以及血清IL-2和IL-10浓度。结果:D1组术后4 h时VAS高于D2组(P0.05);D1组T1、T2时点CD3+、CD4+水平以及CD4+/CD8+比值和NK细胞水平高于D2组(P0.05);D1组T2时血清IL-2浓度高于D2组(P0.05)。结论:地佐辛对于乳腺癌根治术患者术后细胞免疫功能的抑制作用和细胞因子的调节作用呈剂量依赖性。
[Abstract]:Aim: to observe the effects of different doses of dizosin on T lymphocyte subsets, NK cells, IL-2 and IL-10 concentrations in patients with breast cancer after radical mastectomy. Methods: forty patients undergoing radical mastectomy were randomly divided into D 1 group and D 2 group with 20 cases in each group. Intravenous analgesia was induced by intravenous injection of dizosin 0.2 mg/kg, in patients with (PCIA) dizosin 0.5 mg/kg (D1 group) or 0.8 mg/kg (D2 group). VAS scores were recorded before anesthesia (T 0), after operation (T 1), 1 (T 2), 3 (T 3), 7 d (T 4) to detect T lymphocyte subsets (CD3, CD4). CD8 level and CD4 / CD8 ratio), NK cell level and serum IL-2 and IL-10 concentrations. Results: VAS in D1 group was higher than that in D2 group at 4 h after operation (P0.05), CD3, CD4, CD4 / CD8 ratio and NK cell level in D1 group were higher than those in D2 group at T2 time point (P0.05); serum IL-2 concentration in D1 group was higher than that in D2 group at T2 point (P0.05). Conclusion: the inhibitory effect of dizosin on the cellular immune function and the regulation of cytokines in patients with breast cancer after radical mastectomy are dose-dependent.
【作者单位】：佛山市第二人民医院麻醉科;佛山市第二人民医院检验科;佛山市第二人民医院胸外科;中山大学附属第一医院麻醉科;
【基金】：广东省科技计划项目(编号:2012A030400042)
【分类号】：R614;R737.9

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