盐酸戊乙奎醚结合麻黄碱预防芬太尼咳嗽反应的临床观察

发布时间：2019-05-24 13:09

【摘要】：目的 :观察盐酸戊乙奎醚结合麻黄碱预防芬太尼咳嗽反应的作用。方法 :50例在全身麻醉下行择期手术患者,随机分为盐酸戊乙奎醚组(P组)和对照组(C组)。均不用术前药,入室后P组静注静注6mg麻黄碱、盐酸戊乙奎醚0.015mg/kg(生理盐水稀释至5ml),C组静注等量生理盐水,15min后两组静注芬太尼3μg/kg,注射时间3s,记录注射后2min内咳嗽反应发生情况,监测盐酸戊乙奎醚注射前(T1)、芬太尼注射前(T2)、芬太尼注射后2min或咳嗽反应发生后(T3)的收缩压(SBP)、舒张压(DBP)和心率(HR)。结果:P组和C组的咳嗽反应发生率分别为8%和40%,P组明显低于C组,差异有统计学意义(P0.01)。与C组比较,P组T3时SBP、DBP明显降低,差异均有统计学意义(P0.05)。C组T3时SBP明显高于T1时,差异有统计学意义(P0.05)。结论:盐酸戊乙奎醚0.015mg/kg静注结合麻黄碱可有效预防芬太尼诱发的咳嗽反应。
[Abstract]:Objective: to observe the effect of pentylequine hydrochloric acid combined with ephedrine on cough reaction of fentanyl. Methods: fifty patients undergoing elective surgery under general anesthesia were randomly divided into two groups: group P (group P) and group C (control group). No preoperative medication was used. Group P was intravenously injected with 6mg ephedrine and pentane 0.015mg/kg (saline diluted to 5ml), C group by intravenous injection of the same amount of normal saline, and after 15min, fentanyl 3 渭 g / kg, was injected intravenously for 3 s). The occurrence of cough reaction in 2min after injection was recorded. The systolic blood pressure (SBP), was monitored before injection of pentylenequine (T1), before injection of fentanil (T2), after injection of 2min or after cough reaction (T3). Diastolic blood pressure (DBP) and heart rate (HR). Results: the incidence of cough reaction in group P and group C was 8% and 40%, respectively. the incidence of cough reaction in group P was significantly lower than that in group C (P 0.01). Compared with group C, SBP,DBP in group P decreased significantly at T3, and the difference was statistically significant (P 0.05). The SBP in T3 group was significantly higher than that in T1 group (P 0.05). Conclusion: intravenous injection of pentylequine 0.015mg/kg combined with ephedrine can effectively prevent cough reaction induced by fentanyl.
【作者单位】：四川省成都现代医院;四川省广元市第二人民医院;
【分类号】：R614

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