骨科手术中帕瑞昔布钠复合地佐辛超前镇痛效果观察

发布时间：2019-06-17 20:00

【摘要】：目的探讨帕瑞昔布钠复合地佐辛对胫腓骨骨折切开复位内固定手术患者超前镇痛的效果。方法择期行胫腓骨骨折切开复位内固定手术患者120例,随机分为四组各30例。麻醉诱导后切皮前20 min,C组静脉注射生理盐水5 m L,P组静脉注射帕瑞昔布钠40 mg,D组静脉注射地佐辛0.1 mg/kg,PD组静脉注射帕瑞昔布钠40mg和地佐辛0.1 mg/kg。术毕记录苏醒时间、意识恢复时间、拔管时间、拔管后10 min Riker镇静躁动评分(SAS);记录术后1、2、4、12、24 h的静、动态VAS评分及MAP、HR、Sp O2;记录术后24 h内按压镇痛泵次数。结果四组苏醒时间、拔管时间、意识恢复时间、MAP、HR、Sp O2、术后24 h内按压镇痛泵次数差异无统计学意义(P均0.05)。与C组比较,PD组的Riker镇静躁动评分降低(P0.05)。与P组、D组比较,PD组术后1、2、12 h静、动态VAS评分均降低(P均0.05)。结论帕瑞昔布钠复合地佐辛对胫腓骨骨折切开复位内固定手术患者超前镇痛的效果优于单独应用帕瑞昔布钠或地佐辛。
[Abstract]:Objective to investigate the effect of parexib sodium combined with dizoxine on preemptive analgesia in patients undergoing open reduction and internal fixation of tibia and fibula fracture. Methods 120 patients undergoing open reduction and internal fixation of tibia and fibula fractures were randomly divided into four groups (n = 30). After anaesthesia induction, normal saline 5 mL was injected intravenously in 20 min,C group before anesthesia induction, parexib sodium 40mg was injected intravenously in group P, and parexib sodium 40mg and dizoxacin 0.1 mg/kg. were injected intravenously in group D with dizoxacin 0.1 mg/kg,PD. The recovery time and consciousness recovery time were recorded at the end of operation. 10 min Riker sedation and restlessness score after extubation were recorded at 1, 2, 4, 12, 24 h static and dynamic VAS scores and MAP,HR,Sp O 2, and the number of pressing analgesia pumps within 24 hours after extubation was recorded. Results there was no significant difference in recovery time, extubation time, consciousness recovery time, MAP,HR,Sp O 2 and the times of pressing analgesia pump within 24 hours after operation. Compared with group C, the score of Riker sedation and restlessness in PD group was lower than that in group C (P 0.05). Compared with group P and group D, the scores of static and dynamic VAS in PD group were decreased at 1 h, 2 h and 12 h after operation (all P 0.05). Conclusion the effect of parexib sodium combined with dizoxine on preemptive analgesia in patients undergoing open reduction and internal fixation of tibia and fibula fracture is better than that of parexib sodium or dizoxacin alone.
【作者单位】：宁夏医科大学;宁夏医科大学总医院;
【分类号】：R614

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