丙泊酚与右美托咪定在腹腔镜下盆腔脓肿清除术中全麻效果及安全性的比较
发布时间：2019-08-08 18:50
【摘要】：目的 :比较丙泊酚与右美托咪定在腹腔镜下盆腔脓肿清除术中的全身麻醉效果及安全性。方法:将136例拟行盆腔脓肿清除术的女性患者随机均分为丙泊酚组和右美托咪定组。丙泊酚组患者采用DIPRIFUSOR靶控输注系统注入丙泊酚注射液,初始血药浓度为0.5 mg/L,等待与效应室浓度平衡后,以0.3 mg/L维持血药浓度并逐渐递增至适宜的镇静深度,于关闭腹膜时停止给予丙泊酚。右美托咪定组患者给予盐酸右美托咪定注射液0.5μg/kg泵注10 min,并以0.5μg/(kg·h)持续泵注,于腹腔冲洗前停止泵注右美托咪定。观察两组患者意识消失时间、意识恢复时间,输入镇静药物前(T1)、术中30 min(T2)、手术完毕患者清醒后(T3)不同时间点的脑电双频指数(BIS)及不良反应发生情况。结果:右美托咪定组患者意识消失时间、意识恢复时间均显著短于丙泊酚组,两组比较差异有统计学意义(P0.05)。两组患者T1、T3时的BIS比较,差异均无统计学意义(P0.05)。两组患者T2时的BIS均显著低于同组T1、T3时,且右美托咪定组低于丙泊酚组,差异有统计学意义(P0.05)。右美托咪定组患者不良反应发生率显著低于丙泊酚组,两组比较差异有统计学意义(P0.05)。结论:右美托咪定用于腹腔镜下盆腔脓肿清除术的麻醉效果较丙泊酚好,且安全性较好。
[Abstract]:Objective: to compare the effect and safety of propofol and dexmetomide in laparoscopic pelvic abscess removal. Methods: 136 female patients undergoing pelvic abscess removal were randomly divided into propofol group and dexteromide group. Propofol patients in propofol group were injected with propofol injection with DIPRIFUSOR target-controlled infusion system. after the initial blood concentration was 0.5 mg/L, and the concentration of effect chamber was balanced, the plasma concentration was maintained at 0.3 mg/L and gradually increased to a suitable sedation depth. Propofol was stopped when the peritoneum was closed. The patients in the right metomidin group were injected with 0.5 渭 g / kg hydrochloric acid injection for 10 min, and 0.5 渭 g / (kg 路h) for continuous infusion, and the right metomipramine injection was stopped before intraabdominal flushing. The time of consciousness disappearance, the time of consciousness recovery, the occurrence of EEG bispectral index (BIS) and adverse reactions at different time points after awake (T3) were observed before injection of sedation (T1), 30 min (T2) during operation. Results: the consciousness disappearance time and consciousness recovery time of the patients in the right metomipramine group were significantly shorter than those in the propofol group, and there was significant difference between the two groups (P 0.05). There was no significant difference in BIS between the two groups at T 1 and T 3 (P 0.05). The BIS of the two groups at T2 was significantly lower than that of the same group T1, T3, and the right metomidate group was lower than that of propofol group, the difference was statistically significant (P 0.05). The incidence of adverse reactions in dexmetomide group was significantly lower than that in propofol group, and there was significant difference between the two groups (P 0.05). Conclusion: the anesthetic effect and safety of dexmetomide in laparoscopic pelvic abscess removal are better than those of propofol.
【作者单位】： 嵊州市人民医院麻醉科;
【分类号】：R614
，
本文编号：2524536
[Abstract]:Objective: to compare the effect and safety of propofol and dexmetomide in laparoscopic pelvic abscess removal. Methods: 136 female patients undergoing pelvic abscess removal were randomly divided into propofol group and dexteromide group. Propofol patients in propofol group were injected with propofol injection with DIPRIFUSOR target-controlled infusion system. after the initial blood concentration was 0.5 mg/L, and the concentration of effect chamber was balanced, the plasma concentration was maintained at 0.3 mg/L and gradually increased to a suitable sedation depth. Propofol was stopped when the peritoneum was closed. The patients in the right metomidin group were injected with 0.5 渭 g / kg hydrochloric acid injection for 10 min, and 0.5 渭 g / (kg 路h) for continuous infusion, and the right metomipramine injection was stopped before intraabdominal flushing. The time of consciousness disappearance, the time of consciousness recovery, the occurrence of EEG bispectral index (BIS) and adverse reactions at different time points after awake (T3) were observed before injection of sedation (T1), 30 min (T2) during operation. Results: the consciousness disappearance time and consciousness recovery time of the patients in the right metomipramine group were significantly shorter than those in the propofol group, and there was significant difference between the two groups (P 0.05). There was no significant difference in BIS between the two groups at T 1 and T 3 (P 0.05). The BIS of the two groups at T2 was significantly lower than that of the same group T1, T3, and the right metomidate group was lower than that of propofol group, the difference was statistically significant (P 0.05). The incidence of adverse reactions in dexmetomide group was significantly lower than that in propofol group, and there was significant difference between the two groups (P 0.05). Conclusion: the anesthetic effect and safety of dexmetomide in laparoscopic pelvic abscess removal are better than those of propofol.
【作者单位】： 嵊州市人民医院麻醉科;
【分类号】：R614
，
本文编号：2524536
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