阻塞性睡眠呼吸暂停综合征与肾损伤相关性的META分析

发布时间：2018-02-16 12:09

本文关键词： 阻塞性睡眠呼吸暂停肾损伤 Meta分析　出处：《兰州大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：阻塞性睡眠呼吸暂停综合征可引起多系统器官并发症,近年来,阻塞性睡眠呼吸暂停综合征造成的肾脏损害引起较多的关注。血清胱抑素C、尿N-乙酰-β-D氨基葡萄糖苷、尿γ-谷氨酰转移酶、尿素氮、肌酐常用来作为评价肾脏损伤的标志物,本研究通过评价阻塞性睡眠呼吸暂停综合征与上述因子的相关性来反映肾脏的损害。方法：计算机检索PubMed、EMbase、Web of science、Cochrane libray、 CNKI、CBM、VIP、Wanfang Data电子数据库,并手工检索灰色文献及纳入文献的参考文献,检索时间截至2013年12月,全面收集OSAHS与肾损伤相关的队列研究和病例对照研究。由2位评价员独立进行质量评价、数据提取并交叉核对,如有分歧,参考第三方意见。采用RevMan5.2软件进行Meta分析。结果：共纳入6个病例对照研究,包括659例研究对象。Meta分析结果显示：轻、中、重度阻塞性睡眠呼吸暂停综合征患者血清胱抑素C、尿N-乙酰-β-D氨基葡萄糖苷均高于对照组,差异具有统计学意义；中、重度阻塞性睡眠呼吸暂停综合征患者血清肌酐、尿γ-谷氨酰转移酶均高于对照组,差异具有统计学意义；重度阻塞性睡眠呼吸暂停综合征患者血清尿素氮高于对照组,差异具有统计学意义。结论：当前证据表明,阻塞性睡眠呼吸暂停综合征患者存在肾损伤,在血清胱抑素C、尿N-乙酰-β-D氨基葡萄糖苷、尿γ-谷氨酰转移酶、尿素氮、肌酐水平上较正常对照组升高,且与阻塞性睡眠呼吸暂停综合征患者病情严重程度呈正相关。上述结果仍需更高质量、更大样本量的研究进一步证实。
[Abstract]:Objective: obstructive sleep apnea syndrome (OSAS) can cause multiple organ complications. In recent years, more attention has been paid to renal damage caused by obstructive sleep apnea syndrome (OSAS). Urinary 纬-glutamyl transferase, urea nitrogen and creatinine are often used as markers for evaluating renal injury. This study evaluated the correlation between obstructive sleep apnea syndrome (OSAS) and these factors to reflect renal damage. Methods: a computer-based search was conducted for the electronic database of PubMedus EMbase of Science Cochrane lie, CNKI CBM VIPM Wanfang Data, and the grey literature and the references included in the literature were retrieved by hand. The retrieval time was up to December 2013. The cohort study and case-control study of OSAHS related to renal injury were collected. The data were extracted and cross-checked by two evaluators. If there was disagreement, the third party's opinion was consulted. RevMan5.2 software was used for Meta analysis. Results: a total of 6 case-control studies were conducted, including 659 subjects. Meta-analysis showed that serum cystatin C and urinary N-acetyl- 尾 -D-aminoglycoside in patients with mild, moderate and severe obstructive sleep apnea syndrome were higher than those in control group. The serum creatinine and urine 纬-glutamyl transferase in patients with severe obstructive sleep apnea syndrome were significantly higher than those in the control group. The serum urea nitrogen in patients with severe obstructive sleep apnea syndrome was significantly higher than that in the control group. Conclusion: the current evidence indicates that there is renal injury in patients with obstructive sleep apnea syndrome. The levels of serum cystatin C, urine N-acetyl- 尾 -D-glucoside, urinary 纬 -glutamyl transferase, urea nitrogen and creatinine are higher than those in normal control group. There is a positive correlation with the severity of obstructive sleep apnea syndrome.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R766;R692.5

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