利肾化浊汤联合生物制剂治疗下焦湿热型晚期肾癌的临床疗效观察

发布时间：2018-02-16 20:38

本文关键词： 利肾化浊汤晚期肾癌下焦湿热型临床疗效　出处：《湖南中医药大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：探讨中药利肾化浊汤联合生物制剂治疗下焦湿热型晚期肾癌的临床疗效,为晚期肾癌的治疗提供经验。方法：将入选的62例晚期肾癌患者随机分为治疗组和对照组,对照组采用生物制剂干扰素a和白细胞介素2治疗方案。治疗组在对照组生物治疗的基础上给予中药利肾化浊汤内服,6周为1个疗程,1个疗程后进行疗效判定。记录并分析两组患者治疗前后临床疗效和生物制剂的毒副作用。结果：治疗1个疗程后,(1)在瘤体大小方面治疗组有效率为19.35%,对照组总有效率为16.13%,治疗组较对照组有效率高,但无统计学意义(p0.05)； (2)在中医证候评分方面治疗组优于对照组,差异具有统计学意义(P0.05)；在卡氏评分方面治疗组优于对照组,差异具有统计学意义(P0.05)；在提高机体免疫功能方面,治疗组在升高CD3+、CD4+值,降低CD8+值方面优于对照组,差异具有统计学意义(P0.05)；在减轻生物制剂的毒副反应方面治疗组优于对照组,其差异具有统计学意义(P0.05)。结论：在中医理论指导下,在西医常规治疗基础上辨证给予中药利肾化浊汤治疗下焦湿热型晚期肾癌,可改善患者常见的临床症状,提高患者Karnofsky评分,提高患者细胞免疫功能,减轻患者生物反应调节剂治疗导致的毒副反应。
[Abstract]:Objective: To explore the clinical efficacy of Li Shen Hua Tong decoction combined with biologics in the treatment of late renal carcinoma of lower coke and heat type, and to provide experience for the treatment of advanced renal carcinoma.
Methods: a total of 62 patients with advanced renal cell carcinoma patients were randomly divided into treatment group and control group, the control group using biological agents a interferon and interleukin 2 therapy. The treatment group was given TCM kidney Huazhuo Decoction in the control group of biological treatment, 6 weeks for 1 courses, 1 courses to determine the efficacy analysis of two groups of patients before and after treatment. The clinical efficacy and side effects of biological agents and records.
Results: after 1 courses of treatment, (1) in the aspect of tumor size, the effective rate of the treatment group was 19.35%, while the total effective rate of the control group was 16.13%. The effective rate of the treatment group was higher than that of the control group, but it was not statistically significant (P0.05).
(2) the treatment group than the control group in TCM syndrome score, the difference was statistically significant (P0.05); the treatment group than the control group in the Karnofsky score, the difference was statistically significant (P0.05); in the aspect of improving the immune function in the treatment group, CD3+ increased, CD4 + value, reduce the value of CD8+ is better than the control group, the difference was statistically significant (P0.05); to reduce the toxicity of biological agents in the treatment group than the control group, the difference was statistically significant (P0.05).
Conclusion: under the guidance of TCM theory, on the basis of routine western medicine syndrome of damp heat type given the focus of advanced renal cell carcinoma of traditional Chinese medicine kidney Huazhuo decoction, can improve clinical symptoms of patients with common and improve the patients Karnofsky score, improve the cell immune function of the patients, reduce the toxicity associated with biological response modifier therapy.

【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.11

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