ERG和鼠双微体2蛋白在前列腺癌组织中的表达及意义

发布时间：2018-02-24 10:27

本文关键词： 前列腺肿瘤 ERG 鼠双微体　出处：《中国老年学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的检测ERG蛋白和鼠双微体(MDM2)蛋白在前列腺癌组织中的表达情况,并探讨其相关性。方法收集经病理学确诊为前列腺癌标本48例,良性前列腺增生10例,采用免疫组织化学二步法或SP法检测组织标本的ERG蛋白和MDM2蛋白的表达情况,采用χ~2检验及Spearman等级相关分析ERG和MDM2表达与前列腺癌分级的关系。结果前列腺癌组织中ERG和MDM2蛋白阳性表达率分别为33.3%和47.9%,在良性前列腺增生组未见表达,差异有统计学意义(P0.05)。ERG和MDM2蛋白表达与前列腺癌Gleason评分分级不相关(P0.05);但ERG与MDM2蛋白在前列腺癌组织中的表达呈正相关(r=0.831,P=0.001)。结论 ERG和MDM2蛋白在前列腺癌组织中的高表达,与前列腺癌的发生、发展密切相关。前列腺癌中ERG蛋白表达与MDM2蛋白的异常表达密切相关说明这两个蛋白可能存在协同作用。
[Abstract]:Objective to detect the expression of ERG protein and mouse double microsomatic MDM2 protein in prostate cancer and to explore their correlation. Methods 48 cases of prostate cancer and 10 cases of benign prostatic hyperplasia were collected. The expression of ERG protein and MDM2 protein were detected by immunohistochemical two-step method or SP method. 蠂 ~ 2 test and Spearman grade correlation were used to analyze the relationship between the expression of ERG and MDM2 and the grade of prostate cancer. Results the positive expression rates of ERG and MDM2 in prostate cancer were 33.3% and 47.9 respectively, but no expression was found in benign prostatic hyperplasia (BPH). There was a significant difference between the expression of P0.05, ERG and MDM2 protein and the Gleason score of prostate cancer, but the expression of ERG and MDM2 protein was positively correlated with the expression of MDM2 protein in prostate cancer tissue. Conclusion the expression of ERG and MDM2 protein is high in prostate cancer tissue. The expression of ERG protein and abnormal expression of MDM2 protein in prostate cancer are closely related to the occurrence and development of prostate cancer, indicating that these two proteins may have synergistic effects.
【作者单位】：天津市海河医院超声科;宁夏医科大学总医院放射科;宁夏医科大学生殖与遗传重点实验室;
【基金】：宁夏自然科学基金资助项目(NZ13280;NZ1234)
【分类号】：R737.25

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