α-硫辛酸联合枸橼酸他莫昔芬治疗少弱精子症的疗效观察

发布时间：2018-03-08 17:58

本文选题：硫辛酸　切入点：左卡尼汀　出处：《河北医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨α-硫辛酸联合枸橼酸他莫昔芬对少弱精子症患者的疗效观察。方法:选择2016年6月至11月在河北省医科大学第二医院男科门诊就诊的60例少弱精子症患者,将其随机分为2组,每组30例,A组给予α-硫辛酸(0.6g 1次/日)联合枸橼酸他莫昔芬(20mg 1次/日)口服治疗,B组给予左卡尼汀(1g 2次/日)联合枸橼酸他莫昔芬(20mg 1次/日)口服治疗,治疗前及治疗后3个月检测所有病例精液参数及精液氧化应激生物标志物,包括丙二醛(Methylenedioxyamphetamine,MDA)、总抗氧能力(Total antioxidants capacity,TAC)水平,同时了解配偶妊娠率及不良反应发生情况。结果:57例患者完成了全部治疗,包括A组28例,B组29例。A组和B组在精液量、精子浓度、前向运动精子、精浆TAC和MDA方面较用药前均有显著改善(P0.05),在改善精浆TAC方面A组优于B组(P0.05),余两组之间差异无统计学意义(P0.05),两组的正常精子形态百分率比较,治疗前后无统计学差异(P0.05)。治疗3个月后女方妊娠者,A组3例,B组1例,两组比较无统计学意义(P0.05),治疗期间所有患者均未见明显不良反应。结论:α-硫辛酸联合枸橼酸他莫昔芬可明显改善氧化应激损伤,进而改善少弱精子症男性不育患者的精液质量参数,安全有效。
[Abstract]:Objective: to investigate the efficacy of 伪 -lipoic acid combined with tamoxifen citrate in the treatment of oligozoospermia. Methods: sixty patients with oligozoospermia were selected from June 2016 to November in Department of andrology, second Hospital of Hebei Medical University. They were randomly divided into two groups. Group A (n = 30) was treated with 伪 -lipoic acid (0.6g / d) and tamoxifen citrate (20mg / d). Group B was treated with L-carnitine (1g / d) and tamoxifen citrate (20mg / d). Semen parameters and biomarkers of oxidative stress in semen were detected before and 3 months after treatment, including malondialdehyde (MDA) Methylenedioxyamphetamine (MDAA) and total antioxidants capacity (TACc). Results A total of 57 cases were treated, including 28 cases in group A, 29 cases in group B, and 29 cases in group B. the spermatozoa volume, sperm concentration, forward motility spermatozoa were observed in group A and B, respectively. The seminal plasma TAC and MDA were significantly improved compared with those before treatment. Group A was better than group B in improving the seminal plasma TAC. There was no significant difference between the other two groups, and the percentage of normal sperm morphology in the two groups was higher than that in the other two groups. There was no statistical difference before and after treatment (P 0.05). After 3 months of treatment, there were 3 cases in group A and 1 case in group B. There was no significant difference between the two groups (P 0.05) and no significant adverse reactions were observed in all patients during the treatment. Conclusion: 伪 -lipoic acid combined with tamoxifen citrate can significantly improve oxidative stress injury. Then improve the semen quality parameters of oligoasthenospermia male infertility patients, safe and effective.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R698.2

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