脑转移性管状囊性肾细胞癌1例并文献复习

发布时间：2018-03-18 18:45

本文选题：肾细胞肿瘤　切入点：转移性　出处：《临床与实验病理学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨管状囊性肾细胞癌(tubulocystic renal cell carcinoma,TRCC)的临床病理特征、诊断与鉴别诊断。方法对1例60岁男性患者额部转移性TRCC行HE及免疫组化En Vison两步法染色,光镜下观察组织形态学特征,并复习相关文献。结果镜下可见肿瘤由纤细的纤维性间质分隔的大小不等的囊状和小管结构组成,囊腔内含嗜伊红蛋白,囊腔内衬覆扁平或柱状上皮细胞,部分呈“鞋钉样”突向腔内。细胞核圆形或卵圆形,空泡状,可见核仁,Fuhrman核3级,核分裂象不易见,胞质丰富,嗜酸性。免疫表型:肿瘤细胞vimentin、P504s、CK19、CKpan和EMA均呈弥漫强阳性,CD10和CK7均呈阴性,Ki-67增殖指数5%。结论 TRCC十分罕见,好发于成年男性,大部分患者预后良好,复发和转移者罕见,转移性病灶依赖于病理学诊断,并为原发灶的查找提供重要线索和依据。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of tubular cystic renal cell carcinoma (renal cell carcinomata cell). Results the tumor was composed of fine fibrous mesenchymal mesenchymal mesenchymal cysts and tubules with eosinophils in the cysts. The cystic cavity was lined with flat or columnar epithelial cells, some of which were "shoe-like" protruding into the cavity. The nucleus was round or oval, vacuolated, and Fuhrman nuclear grade 3 could be seen. The mitotic appearance was not easy to see and the cytoplasm was abundant. Eosinophilic and immunophenotype: tumor cell line P504sCCK19CKpan and EMA were both strongly diffusely positive, CD10 and CK7 were both negative. Conclusion TRCC is very rare in adult males. The prognosis of most of the patients is good, and recurrence and metastasis are rare. Metastatic lesions depend on pathological diagnosis and provide important clues and evidences for finding primary lesions.
【作者单位】：福建中医药大学附属人民医院病理科;南京军区福州总医院病理科;
【分类号】：R737.11

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