泌尿生殖道感染患者性传播疾病病原体分布及耐药性分析

发布时间：2018-06-04 18:52

本文选题：泌尿生殖道 + 沙眼衣原体　；参考：《中华医院感染学杂志》2015年03期

【摘要】：目的分析医院泌尿生殖道感染患者沙眼衣原体(Ct)、淋菌(NG)、解脲脲支原体(Uu)性传播疾病病原体分布特点,为临床用药提供参考。方法采集2013年1月-2014年5月647例泌尿生殖道感染患者的尿道或宫颈分泌物,采用多重荧光定量PCR(FQ-PCR)技术检测Ct、NG、Uu基因,分析3种病原体分布并进行药敏试验。结果 647份标本中有311份检出病原体,阳性率为48.07%;单一感染204例占65.59%、混合感染107例占34.61%,女性总阳性率为52.57%,高于男性的42.76%,差异有统计学意义(P0.05);20~40岁患者总阳性率高于其他年龄段患者总阳性率,差异有统计学意义(P0.05);Ct对氯霉素、多西环素敏感率分别为97.22%、95.83%;NG对阿奇霉素、左氧氟沙星的敏感率均为96.30%;Uu对交沙霉素、米诺环素的敏感率分别为96.55%、95.40%。结论医院泌尿生殖道感染患者Ct、NG、Uu感染率较高,临床应结合3种病原体感染差异及药敏试验,制定治疗方案。
[Abstract]:Objective to analyze the distribution of pathogens of sexually transmitted diseases of Chlamydia trachomatis, Neisseria gonorrhoeae and Ureaplasma Urealyticum in patients with urogenital tract infection in hospital, and to provide reference for clinical use of drugs. Methods the urethral or cervical secretions of 647 patients with genitourinary tract infection from January 2013 to May 2014 were collected and detected by multiplex fluorescence quantitative PCR FQ-PCR technique. The distribution of three pathogens was analyzed and drug sensitivity tests were carried out. Results the pathogens were detected in 311 of 647 specimens. The positive rate was 48.07% in 204 cases of single infection and 34.61% in 107 cases of mixed infection. The total positive rate of female was 52.57, which was higher than that of male (42.76%). The total positive rate of 2040 years old patients with single infection was higher than that of other age group. The sensitivity rates of doxycycline to azithromycin and levofloxacin to azithromycin were 97.22 and 97.22, respectively. The sensitivity rates of levofloxacin to josamycin and minocycline were 96.55 and 95.40, respectively. Conclusion the infection rate of CTG UU in patients with genitourinary tract infection in hospital is high. The clinical treatment should be combined with the difference of infection of three pathogens and drug sensitivity test.
【作者单位】：台州市第二人民医院皮肤科;
【基金】：浙江省卫生厅基金资助项目(2007-B238)
【分类号】：R691.3;R446.5

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