迈之灵联合常规药物治疗精索静脉曲张的临床研究

发布时间：2018-06-10 05:56

本文选题：精索静脉曲张 + 迈之灵　；参考：《中国药房》2017年26期

【摘要】：目的:探讨迈之灵联合常规药物治疗精索静脉曲张(VC)的临床效果。方法:选择2015年2月-2016年1月我院收治的86例VC患者为研究对象,按照就诊单双号分为对照组和观察组,各43例。对照组患者给予常规药物(枸橼酸氯米芬、左卡尼汀)治疗;观察组患者在对照组基础上加用迈之灵片300 mg,po,bid。两组患者疗程均为3个月。比较两组患者的临床疗效,治疗前后的睾丸动脉血流动力学参数、精浆实验室检查指标、精液质量,以及不良反应发生情况。结果:观察组患者的总有效率为90.70%,明显高于对照组的72.09%,差异有统计学意义(P0.05)。治疗前,两组患者的上述指标比较,差异均无统计学意义(P0.05)。治疗后,两组患者睾丸动脉向心支的收缩期峰值流速、阻力指数和搏动指数均较治疗前明显降低,α-葡糖苷酶、精浆酸性磷酸酶、精浆果糖含量和前向运动精子活动率、精子总活动率均较治疗前明显升高,精子密度均较治疗前明显增大,且观察组各指标均优于对照组,差异均有统计学意义(P0.05);但治疗前后两组患者睾丸动脉向心支的舒张末期流速比较,差异均无统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:迈之灵联合常规药物有助于改善VC患者睾丸动脉血流状态,调节精浆相关分子含量,提高精液质量,从而提高临床疗效,且安全性较高。
[Abstract]:Objective: to investigate the clinical effect of Maxiling combined with conventional medicine in the treatment of varicocele. Methods: 86 patients with VC in our hospital from February 2015 to January 2016 were selected and divided into control group (43 cases) and observation group (43 cases). The patients in the control group were treated with conventional drugs (clomiphene citrate, levacarnitine), and the patients in the observation group were treated with 300 mg of meziline on the basis of the control group. The course of treatment was 3 months in both groups. The clinical efficacy, parameters of testicular artery hemodynamics, seminal plasma laboratory examination, semen quality and adverse reactions were compared between the two groups. Results: the total effective rate of the patients in the observation group was 90.70, which was significantly higher than that in the control group (72.09), and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference in the above indexes between the two groups (P 0.05). After treatment, the peak systolic velocity, resistance index and pulsatile index of the concentric branch of the testicular artery were significantly decreased, 伪 -glucosidase, seminal plasma acid phosphatase, seminal plasma fructose content and forward motility rate of spermatozoa were significantly decreased in both groups. The total motility rate of spermatozoa was significantly higher than that before treatment, and the sperm density was significantly higher than that before treatment, and the indexes of the observation group were better than those of the control group. The difference was statistically significant (P 0.05), but there was no significant difference in end-diastolic velocity of the concentric branch of testicular artery between the two groups before and after treatment. No significant adverse reactions occurred in both groups. Conclusion: Maxiline combined with conventional drugs can improve the blood flow of testicular artery in patients with VC, regulate the content of seminal plasma related molecules, improve the quality of semen, thus improve the clinical efficacy, and the safety is higher.
【作者单位】：南阳市第二人民医院泌尿外科;
【分类号】：R697.24

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