urinary tract infection pathogen drug susceptibility anti

  本文关键词：泌尿系感染患者病原菌分布及药物敏感性分析，由笔耕文化传播整理发布。

泌尿系感染患者病原菌分布及药物敏感性分析

Analysis of drug sensitivity and distribution of pathogens in patients with urinary tract infections

[1] [2] [3] [4]

YUAN Shuqiao, BAN Lisu, ZHAO Qiang, ZHANG Liwen（ 1Department of Clinical Laboratory, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;

[1]兰州大学第一医院检验科,甘肃兰州730000; [2]河北省武安市妇幼保健院,河北武安056300; [3]解放军总医院,北京100853

文章摘要：目的分析泌尿系感染患者病原菌的分布及药物敏感性特征,为临床泌尿系感染的治疗提供依据。方法对2014年1-12月就诊于解放军总医院肾病科门诊的953例泌尿系感染患者的953份尿标本同时进行支原体、细菌培养鉴定和药物敏感性试验。结果953例泌尿系感染患者中,395例支原体培养阳性,阳性检出率41.45%,对美满霉素和强力霉素敏感率〉90%;154例细菌培养阳性,阳性检出率16.16%,分离菌株156株,大肠埃希菌71株占首位,其次为草绿色链球菌14株、粪肠球菌12株、肺炎克雷伯菌11株、无乳链球菌11株等,大肠埃希菌和肺炎克雷伯菌超广谱β-内酞胺酶阳性率分别为45.07%和18.18%,未发现对亚胺培南、美罗培南耐药的大肠埃希菌和肺炎克雷伯菌,以及对万古霉素、利奈唑胺耐药的草绿色链球菌、粪肠球菌和无乳链球菌。结论泌尿系感染患者病原菌以解脲支原体和大肠埃希菌为主,及时监测病原菌的种类分布及药物敏感性特征,对泌尿系感染疾病的治疗有重要意义。

Abstr：Objective To analyze the drug sensitivity and distribution of pathogens in patients with urinary tract infections, and provide basis for clinical treatment of urinary tract infection. Methods From January 2014 to December 2014, the identification and drug sensitivity testing were performed simultaneously for Mycoplasma and bacteria were isolated from urine specimens that were obtained from the outpatients of nephropathy department. Results Of the 953 patients with urinary tract infection, 395 cases were positive in mycoplasma culture, with the positive rate of 41.45% and the susceptibility rate of more than 90% to Doxycycline and Minocycline; 154 cases were positive in bacterial culture, with the positive rate of 16.16%; 156 strains were isolated, and Escherichia coli was the main pathogen （71 strains, accounting for 45.51%）, followed by Streptococcus viridans （14 strains, 8.97%）, Enterococcus （12 strains, 7.69%）, Klebsiella pneumonia （11 strains, 7.05%）, Streptococcus agalactiae （11 strains, 7.05%）. ESBL positive rates of Escherichia coli and Klebsiella pneumonia were 45.07% and 18.18%, respectively. No strains of Escherichia coli and Klebsiella pneumonia were found resistant to Imipenem or Meropenem, and no strains of Streptococcus viridans, Enterococcus, Streptococcus agalactiae were found resistant to Vancomycin or Linezolid. Conclusion Mycoplasma urealytium and Escherichia coli are the main pathogens in patients with urinary tract infection. Monitoring of species distribution and drug sensitivity characteristics of pathogens is important for the treatment of urinary infection diseases.

文章关键词：

Keyword：:urinary tract infection pathogen drug susceptibility anti-bacterial agents

  本文关键词：泌尿系感染患者病原菌分布及药物敏感性分析，由笔耕文化传播整理发布。