XRCC1基因rs25487位点多态性与陕西回族男性人群非梗阻性无精症的相关性

发布时间：2018-10-25 13:41

【摘要】：目的探讨X线修复交叉互补(XRCC1)基因rs25487位点多态性在陕西回族非梗阻性无精症人群中的分布及其与非梗阻性无精症发病风险的关联。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)。方法检测79例陕西回族非梗阻性无精症患者和82例陕西回族正常对照男性人群XRCC1基因rs25487位点的基因分型和等位基因频率,分析其与非梗阻性无精症发病的相关性。结果与GG基因型的个体相比,携带GA基因型的个体患非梗阻性无精症的风险是携带GG基因型个体的2.286倍;携带AA基因型的个体患非梗阻性无精症的风险是GG基因型个体的2.202倍;携带GA+AA基因型的个体患非梗阻性无精症的风险是GG基因型的2.271倍。与G等位基因相比,携带A等位基因的个体患非梗阻性无精症的风险是G基因的1.158倍。结论 XRCC1基因rs25487位点G→A与陕西回族人群非梗阻性无精症发病风险存在关联。
[Abstract]:Objective to investigate the distribution of rs25487 locus polymorphism of X-ray repair crossover complement (XRCC1) gene in Shaanxi Hui non-obstructive azoospermia and its association with the risk of non-obstructive azoospermia. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used. Methods the genotyping and allelic frequency of XRCC1 gene rs25487 locus were detected in 79 non-obstructive azoospermia patients in Shaanxi Hui nationality and 82 healthy controls in Shaanxi Hui nationality, and the correlation between rs25487 locus and the incidence of non-obstructive azoospermia was analyzed. Results compared with individuals with GG genotype, individuals with GA genotype were 2.286 times more likely to suffer from non-obstructive azoospermia than those with GG genotype, individuals with AA genotype were 2.202 times more likely to develop non-obstructive azoospermia than those with GG genotype. Individuals with GA AA genotypes were 2.271 times more likely to develop non-obstructive azoospermia than those with GG genotypes. Individuals with A allele were 1.158 times more likely to develop non-obstructive azoospermia than those with G allele. Conclusion there is an association between the rs25487 locus of XRCC1 gene and the risk of non-obstructive azoospermia in Shaanxi Hui population.
【作者单位】：西安交通大学医学部病理系;西北妇女儿童医院生殖中心;西安交通大学第二附属医院泌尿外科;
【基金】：国家自然科学基金资助项目(No.81273018,30700654) 陕西省自然科学基金资助(No.2015JM8436) 陕西省卫生厅基金(No.2012D58) 中央高校基本科研业务费(No.XJJ2011024)~~
【分类号】：R698.2

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