中国成人及老年人群慢性肾脏病患病率Meta分析

发布时间：2018-11-05 18:22

【摘要】：目的获取中国成人及老年人慢性肾脏病(CKD)患病率。方法检索Pub Med、Sino Med、CNKI、维普、万方2007~2017年有关中国成人CKD流行病学调查研究对性别、老年、蛋白尿、血尿、肾小球滤过率(e GFR)下降(60 ml/min)及地理分区进行亚组分析,并与中国大型横断面研究比较。结果最终纳入文献28篇,总调查161 084例,Egger回归显示不存在发表偏倚(P0.05)。中国成人CKD未标化患病率为13.39%,女性患病率为14.41%,男性10.17%,60岁及以上老年人群患病率19.25%,60岁以下人群8.71%;蛋白尿、血尿及e GFR下降未标化患病率分别为7.30%、5.79%和2.59%;与中国大型横断面研究结果一致。西南地区CKD患病率最高为15.08%,华南地区最低(10.33%)。结论中国成人CKD患病率较高,老年人群尤为显著,单组率Meta分析结果可靠,加强CKD早期诊断及有效干预十分必要。
[Abstract]:Objective to investigate the prevalence of chronic kidney disease (CKD) in Chinese adults and the elderly. Methods Pub Med,Sino Med,CNKI, Viper, Wanfang 2007- 2017 Chinese adult CKD epidemiological study on gender, elderly, proteinuria, hematuria, Glomerular filtration rate (e GFR) decreased (60 ml/min) and geographic subgroup analysis was performed, and compared with large cross-sectional study in China. Results 28 articles were included and 161,084 cases were investigated. Egger regression showed that there was no publication bias (P0.05). The unstandardized prevalence rate of CKD in Chinese adults was 13.39, the prevalence rate of female was 14.41, and the prevalence rate of male 10.17 was 19.25% and below 60 years old. The unstandardized prevalence of proteinuria, hematuria and e GFR decrease was 7.3079% and 2.59%, respectively, which was consistent with the results of large cross-sectional studies in China. The prevalence rate of CKD was the highest in southwest China (15.08%) and the lowest in South China (10.33%). Conclusion the prevalence of CKD in Chinese adults is high, especially in the elderly. The results of single group Meta analysis are reliable. It is necessary to strengthen the early diagnosis and effective intervention of CKD.
【作者单位】： 海南医学院第一附属医院肾内科;海南医学院第一附属医院血透科;
【基金】：国家自然科学基金项目(No.81660131)
【分类号】：R692

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