高尿酸血症对特发性膜性肾病临床及病理的影响

发布时间：2018-12-10 19:39

【摘要】：目的:探讨高尿酸血症对特发性膜性肾病(IMN)的临床及病理的影响。方法:回顾分析2014年1月至2016年6月在广西医科大学第一附属医院肾内科确诊为IMN的314例患者临床及病理特征,并分析高尿酸血症对IMN临床及病理的影响。结果:(1)314例IMN患者高尿酸血症发病率为23.2%(73例);(2)IMN伴高尿酸血症患者的年龄、病程、血压和症状等临床资料与正常尿酸IMN患者间的差异有统计学意义(P0.05);(3)IMN伴高尿酸血症患者血脂和肾功能等实验室指标较正常尿酸水平IMN患者间差异有显著性(P0.05);(4)IMN伴高尿酸血症患者的病理损伤较正常尿酸水平IMN肾病患者严重,差异有统计学意义(P0.05)。结论:高尿酸血症可能加重IMN临床及病理损伤,临床应重视尿酸对IMN的影响,采取综合有效的治疗措施,延缓疾病的发展。
[Abstract]:Objective: to investigate the clinical and pathological effects of hyperuricemia on idiopathic membranous nephropathy (IMN). Methods: the clinical and pathological features of 314 patients with IMN diagnosed in Department of Nephrology, first affiliated Hospital of Guangxi Medical University from January 2014 to June 2016 were retrospectively analyzed, and the effects of hyperuricemia on the clinical and pathological features of IMN were analyzed. Results: (1) the incidence of hyperuricemia in 314 patients with IMN was 23.2% (73 cases); (2) the age, course, blood pressure and symptoms of IMN patients with hyperuricemia were significantly different from those of IMN patients (P0.05). (3) the laboratory indexes such as blood lipids and renal function in IMN patients with hyperuricemia were significantly different from those in IMN patients with normal uric acid level (P0.05). (4) the pathological damage in IMN patients with hyperuricemia was more serious than that in IMN nephropathy patients with normal uric acid level (P0.05). Conclusion: hyperuricemia may aggravate the clinical and pathological injury of IMN. It is necessary to pay attention to the effect of uric acid on IMN and take comprehensive and effective treatment measures to delay the development of the disease.
【作者单位】：广西医科大学第一附属医院肾内科;
【基金】：广西科技计划项目(编号:桂科AB16380228) 广西中医药民族医药科研项目(编号:GZZC14-54)
【分类号】：R589.7;R692

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