代谢综合征及其组分对良性前列腺增生早期进展的影响

发布时间：2019-01-02 12:12

【摘要】：目的：探索代谢综合征及其组分对良性前列腺增生早期进展有无影响。方法：从我院体检中心2012年3月至2012年7月进行健康体检的899名中年男性中选取88例诊断为BPH的患者。按照联合国世界卫生组织确定的新的年龄分段，入组对象年龄限定为45-59岁。所有入组对象均详细询问健康史，并根据国际前列腺调查问卷详细询问患者有无下尿路症状及其严重程度，评出国际前列腺症状评分（International Prostatic Syndrome，IPSS）和生活质量评分（Quality ofLife Score，QOL）。所有入组对象均测量身高、体重，并计算体重指数（Body Mass Index，BMI），测量血压，经腹彩超测前列腺体积（Prostate Volume，PV）。每位入组对象均采集清晨空腹血测空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及血PSA。MS的诊断采用2004年中华医学会糖尿病分会提出的诊断标准。根据不同的分组标准，分别对所有入组的88例入组对象进行分组，共有五种分类方法。根据是否合并MS，将所有入组对象分为BPH合并MS的实验组和单纯BPH的对照组，比较两组间前列腺增生的指标差异有无统计学意义。所有入组对象以BMI为分组标准，分为BMI正常组、超重组和肥胖组，比较三组间前列腺增生的指标差异有无统计学意义。另外三种分类方法分别根据有无血脂、血压或血糖异常，将所有入组对象分为TG正常组和高TG组，血压正常组和血压升高组，血糖正常组和高血糖组，分别比较各组前列腺增生的指标差异有无统计学意义。应用SPSS20.0软件包对数据进行统计学分析，计量资料以x±s表示，计数资料用例数、百分比表示。计量资料的组间比较采用t检验，多组间比较采用单因素方差分析，计数资料及率的比较用χ2检验。结果：1.BPH合并MS的实验组与单纯BPH的对照组相比，前列腺体积的差异具有统计学意义（p=0.048），PSA、IPSS、QOLS的差异无统计学意义； 2.超重和肥胖者与体重指数正常者相比，前列腺体积的差异有统计学意义（p=0.011），三组间PSA、IPSS、QOLS的差异无统计学意义； 3.高TG组与TG正常组比较，PV、IPSS、PSA、QOLS比较差异均无统计学意义； 4.血压升高者与血压正常者相比， IPSS的差异有统计学意义（p=0.006），而PV、PSA、QOLS的差异无统计学意义； 5.血糖升高患者与血糖正常者相比， PV的差异有统计学意义（p=0.009），而IPSS、PSA、QOLS的差异无统计学意义结论：1.中年男性BPH患者中，MS对BPH的早期进展有促进作用。 2.中年男性BPH患者中，，MS组分中的超重、肥胖、空腹血糖升高及血压升高对BPH的早期进展有促进作用。 3.中年男性BPH患者中，血脂异常对BPH无明显影响。
[Abstract]:Objective: to explore the effect of metabolic syndrome and its components on the early progression of benign prostatic hyperplasia (BPH). Methods: 88 patients with BPH were selected from 899 middle-aged men who underwent physical examination in our hospital from March 2012 to July 2012. According to the new age segment established by the World Health Organization, the age limit for the group is 45-59 years. All participants were asked about their health history, and according to the International Prostate Survey questionnaire, the patients were asked whether they had lower urinary tract symptoms and their severity. The International Prostate symptom scale (International Prostatic Syndrome,IPSS) and the quality of Life score (Quality ofLife Score,) were evaluated. QOL). Height and weight were measured, body mass index (Body Mass Index,BMI) was calculated, blood pressure was measured and prostate volume (Prostate Volume,PV) was measured by transabdominal color Doppler ultrasound. Fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol were measured in each group. Low density lipoprotein cholesterol and serum PSA.MS were diagnosed according to the diagnostic criteria proposed by the Chinese Medical Association Diabetes Society in 2004. According to the different grouping criteria, 88 cases were grouped into groups, and there were five kinds of classification methods. According to the combination of MS, all the subjects were divided into two groups: the experimental group with BPH with MS and the control group with BPH alone. There was no statistical significance between the two groups in the index of prostatic hyperplasia. All the subjects were divided into normal BMI group, hyperrecombination group and obesity group according to BMI criteria. The other three classification methods were divided into TG normal group and high TG group, normal blood pressure group and elevated blood pressure group, normal blood glucose group and hyperglycemia group, according to whether there were abnormal blood lipids, blood pressure or blood sugar. The index difference of prostatic hyperplasia in each group was statistically significant. The data were analyzed by SPSS20.0 software package. The data were expressed as x 卤s, and the counting data were expressed as the number of cases and the percentage. T test was used to compare measurement data, single factor analysis of variance (ANOVA) was used in multigroup comparison, 蠂 2 test was used to compare counting data and rate. Results: there was significant difference in prostate volume between the experimental group of 1.BPH and MS and the control group of BPH alone (p0. 048), but the difference of PSA,IPSS,QOLS was not statistically significant. 2. There was significant difference in prostate volume between overweight and obese patients and normal BMI group (p0. 011), but there was no significant difference in PSA,IPSS,QOLS among the three groups. 3. There was no significant difference in PV,IPSS,PSA,QOLS between high TG group and normal TG group. 4. The difference of IPSS between patients with elevated blood pressure and normal blood pressure was statistically significant (p0. 006), but the difference of PV,PSA,QOLS was not statistically significant. The difference of PV between patients with hyperglycemia and those with normal blood glucose was statistically significant (p0. 009), but the difference of IPSS,PSA,QOLS was not statistically significant: 1. In middle-aged male patients with BPH, MS promotes the early progression of BPH. 2. In middle-aged male patients with BPH, overweight, obesity, elevated fasting blood glucose and elevated blood pressure in the MS component contributed to the early progression of BPH. 3. In middle-aged male patients with BPH, dyslipidemia had no significant effect on BPH.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R589;R697.3

【参考文献】