肾移植术后肺部感染患者病原菌回顾性分析

发布时间：2019-01-04 16:07

【摘要】：目的：分析我院肾移植术后并发肺部感染患者病原菌分布情况及耐药情况，为临床抗生素使用提供合理依据。方法：回顾性统计2012年1月-2013年12月年我院收治诊断肾移植术后并发肺部感染患者病例，分析其通过痰液或BALF检出的病原菌菌株分布及药敏情况，并对比分析肾移植术后各阶段感染菌株的构成。结果：收治患者190例次，，取得标本481份，检出169株病原菌株，革兰阴性菌株93株，革兰阳性菌株60株，真菌16株。主要细菌株为鲍曼/溶血不动杆菌、肺炎克雷伯菌、溶血葡萄球菌、大肠埃希菌等，主要真菌为白色念珠菌。病原菌株中多重耐药菌株检出率高，混合感染病例约占51.17%。肾移植术后不同时间段肺部感染细菌菌株构成不同。结论：（1）我院肾移植术后肺部感染的病原菌以革兰阴性菌为主；（2）我院肾移植术后肺部感染病原菌多重耐药严重；（3）肾移植术后肺部感染的细菌菌株分布构成与其移植时间有关。
[Abstract]:Objective: to analyze the distribution of pathogenic bacteria and drug resistance in patients with pulmonary infection after renal transplantation in our hospital. Methods: the clinical data of patients with pulmonary infection after renal transplantation from January 2012 to December 2013 were retrospectively analyzed. The distribution and drug sensitivity of pathogenic bacteria detected by sputum or BALF were analyzed. The composition of infected strains in different stages after renal transplantation was analyzed. Results: totally 481 specimens were collected from 190 patients, 169 pathogenic strains, 93 Gram-negative strains, 60 Gram-positive strains and 16 fungi were detected. The main bacteria strains were Baumann / Acinetobacter hemolyticus, Klebsiella pneumoniae, Staphylococcus haemolyticus, Escherichia coli and Candida albicans. The detection rate of multidrug resistant strains in pathogenic strains was high, and mixed infection cases accounted for 51.17%. The composition of bacterial strains of pulmonary infection was different at different time after renal transplantation. Conclusion: (1) Gram-negative bacteria are the main pathogens of pulmonary infection after renal transplantation in our hospital, (2) the pathogens of pulmonary infection after renal transplantation in our hospital are multidrug resistant. (3) the distribution of bacterial strains of pulmonary infection after renal transplantation was related to the time of transplantation.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R699.2

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