膀胱不同部位注射A型肉毒素治疗女性难治性膀胱过度活动症的临床研究

发布时间：2019-05-14 19:51

【摘要】：目的观察膀胱不同部位注射A型肉毒素治疗女性难治性膀胱过度活动症的疗效。方法 40例入选病例,随机分为逼尿肌注射组(A组)、逼尿肌联合三角区注射组(B组),评估患者治疗前及治疗后4周的临床症状(平均每日日间排尿次数、平均每次排尿量、夜尿次数、尿急次数)及尿动力学指标(初始尿意膀胱容量、最大膀胱容量)和OABSS评分、QOL评分情况。结果经过A型肉毒素注射治疗4周后,A组平均每日日间排尿次数、平均每次排尿量、夜尿次数、尿急次数以及OABSS评分,QOL评分、最大膀胱容量均较B组有明显改善(P0.05)。结论 A型肉毒素膀胱内注射治疗难治性膀胱过度活动症疗效好,无明显毒副作用,是治疗难治性膀胱过度活动的经济、有效的新方法;采用逼尿肌联合三角区部位的注射,症状缓解更为明显,值得进一步的研究及推广。
[Abstract]:Objective to observe the effect of botulinum toxin type A injection into different parts of bladder in the treatment of refractory bladder hyperactivity in women. Methods 40 patients were randomly divided into detrusor injection group (group A) and detrusor combined with triangular injection group (group B). The clinical symptoms of the patients before and 4 weeks after treatment (average daily urination times) were evaluated. Average urination volume, nocturnal urine frequency, urination urgency times), urodynamic indexes (initial urinary bladder volume, maximum bladder volume), OABSS score, QOL score. Results after 4 weeks of botulinum toxin A injection treatment, the average daily urination times, average daily urination volume, nocturnal urine frequency, urination urgency times, OABSS score and QOL score in group A were average daily urination times, average urination volume per day, nocturnal urine frequency, urination urgency times, OABSS score and QOL score. The maximum bladder volume was significantly improved compared with group B (P 0.05). Conclusion intravesical injection of botulinum toxin A is effective in the treatment of refractory bladder hyperactivity without obvious toxic and side effects. It is an economical and effective new method for the treatment of refractory bladder hyperactivity. The symptom relief is more obvious by injection of detrusor combined with triangular area, which is worthy of further study and promotion.
【作者单位】：南方医科大学附属佛山妇幼保健院外科;广东省广州市第一人民医院泌尿外科;
【基金】：广东省卫生厅指令性课题(C2013014) 佛山市科技局基金项目(201308077)
【分类号】：R694

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