血清PCT与sICAM-1和sVCAM-1在慢性肾炎患者细菌感染中的应用
发布时间：2019-07-14 18:56
【摘要】：目的探讨血清降钙素原(PCT)、可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)在慢性肾炎合并细菌感染中的应用价值。方法选取2016年1-12月在医院住院治疗的慢性肾炎合并细菌感染为感染组与未合并细菌感染患者为无感染组,各50例,对感染部位分泌物进行细菌培养,检测两组血清sICAM-1、sVCAM-1,PCT。结果 50例患者共培养出病原菌58株,其中革兰阴性菌34株占58.62%,革兰阳性菌24株占41.38%,感染病原菌主要为肺炎克雷伯菌、大肠埃希菌、金黄色葡萄球菌;感染组入院时血清PCT、sICAM-1、sVCAM-1分别为(1.07±0.30)ng/ml、(336.97±56.92)ng/ml、(548.78±82.57)ng/ml,无感染组分别为(0.04±0.01)ng/ml、(246.81±63.05)ng/ml、(432.10±77.52)ng/ml,差异有统计学意义(P0.05);感染组感染控制后血清PCT、sICAM-1、sVCAM-1水平分别为(0.07±0.02)ng/ml、(260.12±60.11)ng/ml、(438.22±72.31)ng/ml低于感染控制前(1.07±0.30)ng/ml、(336.97±56.92)ng/ml、(548.78±82.57)ng/ml,差异有统计学意义(P0.05)。结论慢性肾炎合并细菌感染后血清PCT、sICAM-1、sVCAM-1水平会出现升高,感染控制后以上指标水平会随之下降,检测血清PCT、sICAM-1、sVCAM-1用于慢性肾炎合并细菌感染的诊断及治疗疗效观察有一定临床价值。
[Abstract]:Objective to investigate the value of serum procalcitonin (PCT), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in chronic nephritis complicated with bacterial infection. Methods from January to December 2016, 50 patients with chronic nephritis complicated with bacterial infection and 50 patients without bacterial infection were selected as infection group and 50 patients without bacterial infection in hospital from January to December 2016. The secretions from the infected sites were cultured and serum sICAM-1,sVCAM-1,PCT. was detected. Results A total of 58 strains of pathogenic bacteria were cultured from 50 patients, including 34 strains of Gram-negative bacteria (58.62%) and 24 strains of Gram-positive bacteria (41.38%). The main pathogenic bacteria were Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus. The serum PCT,sICAM-1,sVCAM-1 in the infection group was (1.07 卤0.30) ng/ml, (336.97 卤56.92) ng/ml, (548.78 卤82.57) ng/ml, and (0.004 卤0.001) ng/ml, (246.81 卤63.05) ng/ml, (432.10 卤77.52) ng/ml, in the non-infected group (P 0.05). The serum PCT,sICAM-1,sVCAM-1 levels in the infection group were (0.07 卤0.002) ng/ml, (260.12 卤60.11) ng/ml, (438.22 卤72.31) ng/ml, respectively, which were significantly lower than those before infection control (1.07 卤0.30) ng/ml, (336.97 卤56.92) ng/ml, (548.78 卤82.57) ng/ml, (P 0.05). Conclusion the level of serum PCT,sICAM-1,sVCAM-1 in patients with chronic nephritis complicated with bacterial infection will increase and the level of above indexes will decrease after infection control. The detection of serum PCT,sICAM-1,sVCAM-1 has certain clinical value in the diagnosis and treatment of chronic nephritis complicated with bacterial infection.
【作者单位】： 嘉兴市第二医院肾内科;
【分类号】：R692.3
，
本文编号：2514447
[Abstract]:Objective to investigate the value of serum procalcitonin (PCT), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in chronic nephritis complicated with bacterial infection. Methods from January to December 2016, 50 patients with chronic nephritis complicated with bacterial infection and 50 patients without bacterial infection were selected as infection group and 50 patients without bacterial infection in hospital from January to December 2016. The secretions from the infected sites were cultured and serum sICAM-1,sVCAM-1,PCT. was detected. Results A total of 58 strains of pathogenic bacteria were cultured from 50 patients, including 34 strains of Gram-negative bacteria (58.62%) and 24 strains of Gram-positive bacteria (41.38%). The main pathogenic bacteria were Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus. The serum PCT,sICAM-1,sVCAM-1 in the infection group was (1.07 卤0.30) ng/ml, (336.97 卤56.92) ng/ml, (548.78 卤82.57) ng/ml, and (0.004 卤0.001) ng/ml, (246.81 卤63.05) ng/ml, (432.10 卤77.52) ng/ml, in the non-infected group (P 0.05). The serum PCT,sICAM-1,sVCAM-1 levels in the infection group were (0.07 卤0.002) ng/ml, (260.12 卤60.11) ng/ml, (438.22 卤72.31) ng/ml, respectively, which were significantly lower than those before infection control (1.07 卤0.30) ng/ml, (336.97 卤56.92) ng/ml, (548.78 卤82.57) ng/ml, (P 0.05). Conclusion the level of serum PCT,sICAM-1,sVCAM-1 in patients with chronic nephritis complicated with bacterial infection will increase and the level of above indexes will decrease after infection control. The detection of serum PCT,sICAM-1,sVCAM-1 has certain clinical value in the diagnosis and treatment of chronic nephritis complicated with bacterial infection.
【作者单位】： 嘉兴市第二医院肾内科;
【分类号】：R692.3
，
本文编号：2514447
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