具有多囊卵巢综合征表型绝经女性心血管疾病发病风险研究

发布时间：2018-01-01 23:27

  本文关键词：具有多囊卵巢综合征表型绝经女性心血管疾病发病风险研究　出处：《中国实用妇科与产科杂志》2016年09期 　论文类型：期刊论文

  更多相关文章： 多囊卵巢综合征 绝经 心血管事件

【摘要】：目的探讨具有多囊卵巢综合征(PCOS)表型的绝经女性心血管疾病的发生风险。方法以2005-01-01—2007-12-31于苏州大学附属第二医院健康体检的绝经女性346例为研究对象,根据有无PCOS表型分为2组:PCOS表型组(57例)和非PCOS表型组(289例)。随访以电话随访为主,辅以住院随访、门诊随访等。随访间歇为3个月,随访终点为主要不良心血管事件(MACE),随访截止日期为2014-12-31。生存率估算应用Kaplan-Meier法,组间生存率曲线差异采用log-rank检验,应用多变量Cox比例风险回归分析MACE的独立危险因素。结果非PCOS表型组有10例出现MACE,PCOS表型组有7例出现MACE。Kaplan-Meier曲线显示PCOS表型组无MACE生存率显著下降(χ2=4.754,P=0.023)。多变量Cox比例风险回归分析发现高密度脂蛋白胆固醇(HDL-C)较低、超敏C反应蛋白(hsCRP)较高和存在PCOS表型是MACE的独立预测因素。结论 PCOS表型是绝经女性发生心血管疾病的独立危险因素,有助于进一步行危险分层,且提示PCOS与心血管疾病密切相关。
[Abstract]:Objective to investigate PCOS with polycystic ovary syndrome (PCOS). The risk of cardiovascular disease in menopausal women with phenotype was studied in 346 postmenopausal women who underwent physical examination in the second affiliated Hospital of Suzhou University from January to January 2007-12-31 2005. Elephant. PCOS phenotypes were divided into 2 groups according to the phenotype of PCOS: 57 cases of PCOS phenotype group and 289 cases of non-PCOS phenotype group. Telephone follow-up was the main follow-up followed by in-patient follow-up. Outpatient follow-up and so on. The interval of follow-up was 3 months, and the end point was major adverse cardiovascular events (MACEE). The deadline of follow-up was 2014-12-31. Kaplan-Meier method was used to estimate the survival rate, and the difference of survival curve between groups was evaluated by log-rank test. Multivariate Cox proportional risk regression analysis was used to analyze the independent risk factors of MACE. Results MACE was found in 10 cases of non-#en2# phenotypic group. In 7 cases of PCOS phenotypic group, MACE.Kaplan-Meier curve showed that the MACE free survival rate of PCOS phenotypic group decreased significantly (蠂 2 = 4.754). Multivariate Cox proportional risk regression analysis showed that HDL-C was lower than HDL-C in high density lipoprotein cholesterol (HDL-C). The high sensitivity C-reactive protein hsCRP and the presence of PCOS phenotype are independent predictors of MACE. Conclusion PCOS phenotype is an independent risk factor for cardiovascular disease in postmenopausal women. It is helpful for further risk stratification and suggests that PCOS is closely related to cardiovascular disease.
【作者单位】： 苏州大学附属第二医院妇产科;无锡第四人民医院妇产科;无锡市妇幼保健院妇产科;
【分类号】：R711.75;R54
【正文快照】： 多囊卵巢综合征(PCOS)是一种复杂的内分泌 及代谢异常疾病,以慢性无排卵(排卵功能紊乱或丧失)和高雄激素血症为特征。随着对PCOS研究的增多,发现PCOS不仅仅与不孕关系密切,而且与2型糖尿病、代谢综合征以及心血管疾病的发生、发展相关[1-3]。既往有关PCOS与心血管疾病的研究,，

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