不同剂量碘酸钾与碘化钾治疗Wistar大鼠缺碘性甲状腺肿效果观察

发布时间：2018-01-02 22:19

本文关键词：不同剂量碘酸钾与碘化钾治疗Wistar大鼠缺碘性甲状腺肿效果观察　出处：《中国地方病防治杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨不同剂量碘酸钾和碘化钾治疗Wistar大鼠缺碘性甲状腺肿的效果。方法选取80只健康Wistar大鼠,随机分为A组(70只)和B组(10只)。A组大鼠产生明显甲状腺肿后将其随机分为7组,每组10只。在成功复制缺碘性甲状腺肿大鼠动物模型后,以单倍碘(0.26mg/L)、5倍和50倍的碘酸钾和碘化钾六种方法补碘,分别在1、3个月后检测大鼠绝对和相对甲状腺重量、尿碘含量、组织碘含量、细胞面积/视场面积和胶质面积/视场面积情况。结果各KI组和KIO3组大鼠的绝对和相对甲状腺重量均显著低于对照组,高于B组,差异有统计学意义(P0.05);50倍KI组和50倍KIO_3组大鼠的甲状腺绝对和相对重量显著高于其他KI组和KIO_3组,差异有统计学意义(P0.05)。各KI组和KIO_3组大鼠的尿碘水平显著高于对照组,差异有统计学意义(P0.05);不同补碘水平间的尿碘水平比较差异有统计学意义(P0.05);同一补碘水平的KI组和KIO_3组尿碘水平比较差异无统计学意义(P0.05);各组补碘3个月的尿碘水平均显著高于补碘1个月,差异有统计学意义(P0.05)。各KI组和KIO_3组大鼠的甲状腺组织碘含量显著高于对照组,低于B组,差异有统计学意义(P0.05)。各KI组和KIO_3组的细胞面积/视场面积显著低于对照组,差异有统计学意义(P0.05);在补碘后3个月后,50倍KI组和50倍KIO_3组的细胞面积/视场面积显著低于其余各KI组和KIO3组,差异有统计学意义(P0.05);各KI组和KIO_3组的胶质面积/视场面积显著高于对照组,差异有统计学意义(P0.05)。结论不同剂量碘酸钾和碘化钾均可有效纠正缺碘性甲状腺肿,相同补碘剂量之间的效果相似,而大剂量补碘会损伤甲状腺,适量KIO_3对于纠正碘缺乏具有较好效果,且安全性高。
[Abstract]:Objective to investigate the effects of different doses of potassium iodate and potassium iodide on iodine deficiency goiter in Wistar rats. Methods 80 healthy Wistar rats were selected. Group A (n = 70) and group B (n = 10) were randomly divided into 7 groups (10 rats in each group). The absolute and relative thyroid weight and urinary iodine content in rats were measured 1 and 3 months after iodine supplementation with 5 and 50 times potassium iodate and potassium iodide by 0.26 mg 路L ~ (-1) / L ~ (-1) iodide. Results the absolute and relative thyroid weight of each Ki group and KIO3 group was significantly lower than that of control group and higher than that of B group. The difference was statistically significant (P 0.05). The absolute and relative weight of thyroid gland in 50 times Ki group and 50 fold KIO_3 group was significantly higher than that in other Ki and KIO_3 groups. The level of urinary iodine in Ki group and KIO_3 group was significantly higher than that in control group (P 0.05). The differences of urinary iodine levels among different iodine supplementation levels were statistically significant (P 0.05). There was no significant difference in urinary iodine level between Ki group and KIO_3 group with the same iodine supplementation level (P 0.05). The level of urinary iodine in each group was significantly higher than that in iodine supplementation for 1 month, the difference was statistically significant (P 0.05). The iodine content of thyroid tissue in each Ki group and KIO_3 group was significantly higher than that in control group. The cell area / field area of each Ki group and KIO_3 group was significantly lower than that of the control group (P 0.05). After 3 months of iodine supplementation, the cell area / field of view area in 50 times Ki group and 50 fold KIO_3 group were significantly lower than those in other Ki and KIO3 groups, and the difference was statistically significant (P 0.05). The glial area / field of view area of each Ki group and KIO_3 group was significantly higher than that of the control group. Conclusion different doses of potassium iodate and potassium iodide can effectively correct iodine deficiency goiter. Proper amount of KIO_3 has good effect in correcting iodine deficiency and high safety.
【作者单位】：海南省第三人民医院药剂科;成都市第五人民医院内分泌科;
【基金】：海南省重点科技计划项目;基金编号:ZDXM2014068
【分类号】：R581.3
【正文快照】： 碘缺乏病是因为外环境缺碘而引发机体内无法摄入足够碘,最终阻碍机体生长发育的综合征,其会导致地方性甲状腺肿、先天畸形、地方性克丁病等多种疾病[1]。对人们身体健康和人口素质造成较大影响。我国从20世纪90年代开始实施用碘酸钾(KIO3)代替碘化钾(KI)加工碘盐,并且逐步开始

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